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左旋氨氯地平

左旋氨氯地平

CAS号：103129-82-4

英文名：(S)-Amlodipine

分子式

C20H25ClN2O5

熔点

密度

1.227

分子量

408.876

沸点

527.2ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Levamlodipine (INN), also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine. Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent. Levamlodipine is currently marketed in Russia under the brand name EsCordi Cor (Actavis Pharma) and in India under the trade names Eslo (Zuventus Healthcare Ltd.), Asomex (Emcure Pharmaceutical Ltd.), and Espin (Intas Pharmaceuticals Ltd.).

基本信息

中文名称

左旋氨氯地平

英文名称

(S)-Amlodipine

中文别名

s-氨氯地平、(4S)-2-[(2-氨基乙氧基)甲基]-4-(2-氯苯基)-1,4-二氢-6-甲基-3,5-吡啶二甲酸 3-乙基 5-甲基酯、(S)-氨氯地平

英文别名

l-Amlodipine、Levamlodipine、Lodien、Levoamlodipine Besylate、Levamlodipine Besylate Tablets、LevoaMlodipine

CAS号

103129-82-4

分子式

C20H25ClN2O5

分子量

408.876

精确质量

408.145

PSA

99.88

LOGP

3.2954

编号系统

UNII

0P6NLP6806

物化性质

密度

1.227

沸点

527.2ºC at 760 mmHg

闪点

272.6ºC

折射率

1.546

蒸汽压

0mmHg at 25°C

合成路线

络活喜

左旋氨氯地平

左旋氨氯地平

上游原料

共找到8个上游原料 >

2-[(2-azidoethoxy)methyl]-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

2-[(2-azidoethoxy)methyl]-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine

络活喜

2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-3-(2-cyanoethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-3-(2-cyanoethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

(-)-2-<<2-<(tert-butoxycarbonyl)amino>ethoxy>-methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

(-)-2-<<2-<(tert-butoxycarbonyl)amino>ethoxy>-methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

2-(2-azidoethoxy)methyl-3-carboxy-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

2-(2-azidoethoxy)methyl-3-carboxy-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

(+)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine

(+)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine

上游原料

2-[(2-azidoethoxy)methyl]-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine 络活喜 2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-3-(2-cyanoethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (-)-2-<<2-<(tert-butoxycarbonyl)amino>ethoxy>-methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine 2-(2-azidoethoxy)methyl-3-carboxy-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (+)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine 2-((2-((tert-butoxycarbonyl)amino)ethoxy)-methyl)-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine 2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate