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(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

CAS号：103335-80-4

英文名：(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

分子式：C23H47NO5Si

分子量：445.708

合成路线

(S)-5-((S)-1-azido-3-methylbutyl)dihydrofuran-2(3H)-one

(S)-5-((S)-1-azido-3-methylbutyl)dihydrofuran-2(3H)-one

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(3S,5S)-5-((S)-1-azido-3-methylbutyl)-3-(2-hydroxypropan-2-yl)-dihydrofuran-2(3H)-one

(3S,5S)-5-((S)-1-azido-3-methylbutyl)-3-(2-hydroxypropan-2-yl)-dihydrofuran-2(3H)-one

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(S)-5-((R)-1-hydroxy-3-methylbutyl)dihydrofuran-2(3H)-one

(S)-5-((R)-1-hydroxy-3-methylbutyl)dihydrofuran-2(3H)-one

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(R)-3-methyl-1-((S)-5-oxotetrahydrofuran-2-yl)butyl methanesulfonate

(R)-3-methyl-1-((S)-5-oxotetrahydrofuran-2-yl)butyl methanesulfonate

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

5,6-anhydro-2,3-dideoxy-D-erythro-hexono-1,4-lactone

5,6-anhydro-2,3-dideoxy-D-erythro-hexono-1,4-lactone

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(5S,1'S)-5-(2'-bromo-1'-hydroxy)ethyl-4,5-dihydro-2-(3H)-furanone

(5S,1'S)-5-(2'-bromo-1'-hydroxy)ethyl-4,5-dihydro-2-(3H)-furanone

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

(4S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoic acid

上游原料

(S)-5-((S)-1-azido-3-methylbutyl)dihydrofuran-2(3H)-one (5S,1'S)-5-(2'-bromo-1'-hydroxy)ethyl-4,5-dihydro-2-(3H)-furanone (R)-3-methyl-1-((S)-5-oxotetrahydrofuran-2-yl)butyl methanesulfonate 5,6-anhydro-2,3-dideoxy-D-erythro-hexono-1,4-lactone (3S,5S)-5-((S)-1-azido-3-methylbutyl)-3-(2-hydroxypropan-2-yl)-dihydrofuran-2(3H)-one

下游产品

{(S)-1-[(S)-1-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexylcarbamoyl)-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester