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他比特啶

他比特啶

CAS号：114899-77-3

英文名：trabectedin

分子式：C39H43N3O11S

分子量：761.837

上游原料

tert-butyl (R)-4-((1R,3S)-2-((allyloxy)carbonyl)-8-hydroxy-3-(hydroxymethyl)-7-methoxy-6-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

tert-butyl (R)-4-((1R,3S)-2-((allyloxy)carbonyl)-8-hydroxy-3-(hydroxymethyl)-7-methoxy-6-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

(5aR,6aS,7R,13S,14R,16R)-16-(((tert-butyldiphenylsilyl)oxy)methyl)-5a-hydroxy-9-methoxy-8-(methoxymethoxy)-4,10,17-trimethyl-5-oxo-5,5a,6,6a,7,13,14,16-octahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinoline-14-carbonitrile

(5aR,6aS,7R,13S,14R,16R)-16-(((tert-butyldiphenylsilyl)oxy)methyl)-5a-hydroxy-9-methoxy-8-(methoxymethoxy)-4,10,17-trimethyl-5-oxo-5,5a,6,6a,7,13,14,16-octahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinoline-14-carbonitrile

(S)-N-(((6S,7R,9R,14aS,15R)-7-cyano-1-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)-2-(3-phenylureido)propanamide

(S)-N-(((6S,7R,9R,14aS,15R)-7-cyano-1-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)-2-(3-phenylureido)propanamide

1350888-69-5

tert-butyl ((S)-1-((((6aS,7R,13S,14R,16R)-5-(allyloxy)-14-cyano-9-methoxy-8-(methoxymethoxy)-4,10,17-trimethyl-6,6a,7,13,14,16-hexahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinolin-16-yl)methyl)amino)-1-oxopropan-2-yl)carbamate

tert-butyl ((S)-1-((((6aS,7R,13S,14R,16R)-5-(allyloxy)-14-cyano-9-methoxy-8-(methoxymethoxy)-4,10,17-trimethyl-6,6a,7,13,14,16-hexahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinolin-16-yl)methyl)amino)-1-oxopropan-2-yl)carbamate

2,2,2-trichloroethyl (((6aS,7R,13S,14R,16R)-5-(allyloxy)-14-cyano-9-methoxy-8-(methoxymethoxy)-4,10,17-trimethyl-6,6a,7,13,14,16-hexahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinolin-16-yl)methyl)carbamate

2,2,2-trichloroethyl (((6aS,7R,13S,14R,16R)-5-(allyloxy)-14-cyano-9-methoxy-8-(methoxymethoxy)-4,10,17-trimethyl-6,6a,7,13,14,16-hexahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinolin-16-yl)methyl)carbamate

(6aS,7R,13S,14R,16R)-5-(allyloxy)-8-hydroxy-16-(hydroxymethyl)-9-methoxy-4,10,17-trimethyl-6,6a,7,13,14,16-hexahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinoline-14-carbonitrile

(6aS,7R,13S,14R,16R)-5-(allyloxy)-8-hydroxy-16-(hydroxymethyl)-9-methoxy-4,10,17-trimethyl-6,6a,7,13,14,16-hexahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinoline-14-carbonitrile

tert-butyl (R)-4-((1R,3S)-8-hydroxy-3-(hydroxymethyl)-7-methoxy-6-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

tert-butyl (R)-4-((1R,3S)-8-hydroxy-3-(hydroxymethyl)-7-methoxy-6-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,2-dimethyloxazolidine-3-carboxylate

ecteinascidin 770

ecteinascidin 770

7-((R)-2-hydroxy-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate

7-((R)-2-hydroxy-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate

442663-61-8

7-((R)-2-((tert-butyldiphenylsilyl)oxy)-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate

7-((R)-2-((tert-butyldiphenylsilyl)oxy)-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate

allyl ((1R,2S)-1-((7S,11R)-5-(allyloxy)-4-methyl-8-oxo-7,8,10,11-tetrahydro-6H-7,11-epimino[1,3]dioxolo[4',5':5,6]benzo[1,2-d]oxocin-12-yl)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-cyanopropan-2-yl)carbamate

allyl ((1R,2S)-1-((7S,11R)-5-(allyloxy)-4-methyl-8-oxo-7,8,10,11-tetrahydro-6H-7,11-epimino[1,3]dioxolo[4',5':5,6]benzo[1,2-d]oxocin-12-yl)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-cyanopropan-2-yl)carbamate

3-hydroxy-2-iodo-4-methoxy-5-methylbenzaldehyde

3-hydroxy-2-iodo-4-methoxy-5-methylbenzaldehyde

allyl ((1R,2S)-1-((7S,11R)-5-(allyloxy)-8-hydroxy-4-methyl-7,8,10,11-tetrahydro-6H-7,11-epimino[1,3]dioxolo[4',5':5,6]benzo[1,2-d]oxocin-12-yl)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-cyanopropan-2-yl)carbamate

allyl ((1R,2S)-1-((7S,11R)-5-(allyloxy)-8-hydroxy-4-methyl-7,8,10,11-tetrahydro-6H-7,11-epimino[1,3]dioxolo[4',5':5,6]benzo[1,2-d]oxocin-12-yl)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-cyanopropan-2-yl)carbamate

6-Hydroxy-7-methyl-1,3-benzodioxole-5-carbaldehyde

6-Hydroxy-7-methyl-1,3-benzodioxole-5-carbaldehyde

methyl (S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)propanoate

methyl (S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)propanoate

2-[1-[3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-meth-(E)-ylidene]-malonic acid monomethyl ester

2-[1-[3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-meth-(E)-ylidene]-malonic acid monomethyl ester

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上游原料

4-methoxy-3-(methoxymethoxy)-5-methylbenzaldehyde (2R)-2-((2S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)-N-(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)propanamido)-2-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl acetate 3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzaldehyde ecteinascidin 770 7-((R)-2-hydroxy-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate (3R,5R)-3-(7-hydroxy-6-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl)-6,6-dimethyl-5-phenylmorpholin-2-one 7-((R)-2-((tert-butyldiphenylsilyl)oxy)-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate 5-(methoxymethoxy)-4-methyl-1,3-benzodioxole tert-butyl ((2S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-1-(((R)-2-((tert-butyldiphenylsilyl)oxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate 3-hydroxy-2-iodo-4-methoxy-5-methylbenzaldehyde 6-Hydroxy-7-methyl-1,3-benzodioxole-5-carbaldehyde methyl (S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)propanoate tert-butyl (2S)-4-((R)-2-acetoxy-1-(7-methyl-6-((methylsulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)ethyl)-2-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-5-methyl-3,6-dioxopiperazine-1-carboxylate tert-butyl (S)-4-((R)-2-acetoxy-1-(7-methyl-6-((methylsulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)ethyl)-2-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-5-methyl-3-oxo-3,4-dihydropyrazine-1(2H)-carboxylate Toluene-4-sulfonic acid 5-bromo-2-hydroxy-3-methyl-phenyl ester 2,2,2-trichloroethyl (1R,2R,5S)-10-(benzyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-((R)-2-hydroxy-1-(6-hydroxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)-9-methoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-11-carboxylate (3R,5R,6R,12S,12aS)-2,2,2-trichloroethyl 7-(benzyloxy)-3-[6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-4-yl]-5-{[(tert-butyldimethylsilyl)oxy]methyl}-8-methoxy-9-methyl-3,5,6,11,12,12a-hexahydro-2H-6,12-epiminobenzo[e]oxazolo[3,2-a]azocine-13-carboxylate alcohol compound tert-butyl ((S)-1-((((6S,7R,9R,14aS,15R)-7-cyano-2,11-dimethoxy-1-(methoxymethoxy)-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)amino)-1-oxopropan-2-yl)carbamate 2,2,2-trichloroethyl (1R,5S)-3-((R)-2-acetoxy-1-(6-acetoxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)-10-(benzyloxy)-9-methoxy-8-methyl-2-methylene-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-11-carboxylate 5-(methoxymethoxy)-1,3-benzodioxole nitrile compound 5-bromo-2-methoxy-1-(methoxymethoxy)-3-methylbenzene 2-benzyloxy-3-methyl-4,5-methylenedioxybenzaldehyde (2R)-2-((3S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-6-methyl-2,5-dioxopiperazin-1-yl)-2-(7-methyl-6-((methylsulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)ethyl acetate (R)-2-((tert-butyldiphenylsilyl)oxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethan-1-amine (R)-1-(((R)-2-((tert-butyldiphenylsilyl)oxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)amino)-2-methyl-1-phenylpropan-2-ol tert-butyl ((2S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-1-(((R)-2-hydroxy-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate 5-bromo-2-methoxy-3-methylphenol Trifluoro-methanesulfonic acid 7-((3R,5R)-6,6-dimethyl-2-oxo-5-phenyl-morpholin-3-yl)-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester (S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid methyl (Z)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate 5-(dimethoxymethyl)-2-methoxy-1-(methoxymethoxy)-3-methylbenzene 6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxole-5-carbaldehyde 2,2,2-trichloroethyl (1R,2R,5S)-10-(benzyloxy)-3-((R)-1-(6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-4-yl)-2-hydroxyethyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-9-methoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-11-carboxylate 芝麻酚 tert-butyl ((S)-1-((((6S,7R,9R,14aS,15R)-7-cyano-1-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)amino)-1-oxopropan-2-yl)carbamate 1-allyl 3-(2,2-dimethoxyethyl) 2-((6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-5-yl)methylene)malonate 5-bromo-2-methoxy-3-methylphenyl 4-methylbenzenesulfonate silanylether (2R)-2-((3S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-6-methyl-2,5-dioxopiperazin-1-yl)-2-(6-hydroxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl acetate 2-hydroxy-3-methylphenyl 4-methylbenzenesulfonate tert-butyl (1R,5S)-3-((R)-2-acetoxy-1-(6-acetoxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)-10-(benzyloxy)-9-methoxy-8-methyl-2-methylene-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-11-carboxylate 5-(methoxymethoxy)-1,3-benzodioxol-4-ol (2R)-2-((3S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-6-methyl-2,5-dioxopiperazin-1-yl)-2-(6-hydroxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl acetate tert-butyl ((S)-1-((((6S,7R,9R,14aS,15R)-7-cyano-11-hydroxy-2-methoxy-1-(methoxymethoxy)-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)amino)-1-oxopropan-2-yl)carbamate