百科

9-((3aS,4R,6aR)-6-((2-((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)ethoxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-bis(tert-butoxylcarbonyl)amine

CAS号：1352447-58-5

英文名：9-((3aS,4R,6aR)-6-((2-((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)ethoxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-bis(tert-butoxylcarbonyl)amine

分子式：C37H55N7O9

分子量：741.874

合成路线

1352447-44-9

((3aR,4S,6aR)-6-(allyloxymethyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)(tert-butyl)dimethylsilane

1352447-58-5

9-((3aS,4R,6aR)-6-((2-((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)ethoxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-bis(tert-butoxylcarbonyl)amine

1352447-46-1

2-(((3aR,6S,6aR)-6-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methoxy)ethanol

1352447-58-5

9-((3aS,4R,6aR)-6-((2-((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)ethoxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-bis(tert-butoxylcarbonyl)amine

1352447-48-3

2-(((3aR,6S,6aR)-6-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methoxy)ethyl 4-methylbenzenesulfonate

1352447-58-5

9-((3aS,4R,6aR)-6-((2-((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)ethoxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-bis(tert-butoxylcarbonyl)amine

1352447-54-1

(2S,5R)-2-(2-(((3aR,6S,6aR)-6-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methoxy)ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

1352447-58-5

9-((3aS,4R,6aR)-6-((2-((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)ethoxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-bis(tert-butoxylcarbonyl)amine

1352447-42-7

((3aR,6S,6aR)-6-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

1352447-58-5

9-((3aS,4R,6aR)-6-((2-((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)ethoxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-bis(tert-butoxylcarbonyl)amine

160343-79-3

(3aS,4S,6aR)-6-{{[(1,1-dimethylethyl)dimethylsilyl]oxy}methyl}-3a,6a-dihydro-2,2-dimethyl-4H-cyclopenta[d]-1,3-dioxol-4-ol

1352447-58-5

9-((3aS,4R,6aR)-6-((2-((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)ethoxy)methyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-6-bis(tert-butoxylcarbonyl)amine

上游原料

((3aR,4S,6aR)-6-(allyloxymethyl)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)(tert-butyl)dimethylsilane (2S,5R)-2-(2-(((3aR,6S,6aR)-6-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methoxy)ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine (3aS,4S,6aR)-6-{{[(1,1-dimethylethyl)dimethylsilyl]oxy}methyl}-3a,6a-dihydro-2,2-dimethyl-4H-cyclopenta[d]-1,3-dioxol-4-ol 2-(((3aR,6S,6aR)-6-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methoxy)ethanol ((3aR,6S,6aR)-6-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol 2-(((3aR,6S,6aR)-6-(tert-butyldimethylsilyloxy)-2,2-dimethyl-6,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methoxy)ethyl 4-methylbenzenesulfonate

下游产品

(S)-2-amino-4-(((3R,4S,5R)-3-(6-amino-9H-purin-9-yl)-4,5-dihydroxycyclopent-1-enyl)methoxy)butanoic acid