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(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

CAS号：1353667-08-9

英文名：(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

分子式：C22H32O5

分子量：376.486

合成路线

3-(5-O-acetyl-2,3-O-isopropylidene-β-D-ribofuranosyl)prop-1-ene

3-(5-O-acetyl-2,3-O-isopropylidene-β-D-ribofuranosyl)prop-1-ene

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

((3aR,4R,6S,6aS)-6-(5-(benzyloxy)pentyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate

((3aR,4R,6S,6aS)-6-(5-(benzyloxy)pentyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(3aS,4S,6S,6aS)-4-(5-(benzyloxy)pentyl)-6-(chloromethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

(3aS,4S,6S,6aS)-4-(5-(benzyloxy)pentyl)-6-(chloromethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(S)-6-(benzyloxy)-1-((4S,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl)hexan-1-ol

(S)-6-(benzyloxy)-1-((4S,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl)hexan-1-ol

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

((3aR,4R,6S,6aS)-2,2-dimethyl-6-(2-oxoethyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate

((3aR,4R,6S,6aS)-2,2-dimethyl-6-(2-oxoethyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

((3aR,4R,6S,6aS)-6-((E)-5-(benzyloxy)pent-2-enyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate

((3aR,4R,6S,6aS)-6-((E)-5-(benzyloxy)pent-2-enyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

(4S,5R)-4-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-5-ethynyl-2,2-dimethyl-1,3-dioxolane

上游原料

3-(5-O-acetyl-2,3-O-isopropylidene-β-D-ribofuranosyl)prop-1-ene (3aS,4S,6S,6aS)-4-(5-(benzyloxy)pentyl)-6-(chloromethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole ((3aR,4R,6S,6aS)-6-(5-(benzyloxy)pentyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate (S)-6-(benzyloxy)-1-((4S,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl)hexan-1-ol ((3aR,4R,6S,6aS)-6-((E)-5-(benzyloxy)pent-2-enyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate ((3aR,4R,6S,6aS)-2,2-dimethyl-6-(2-oxoethyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate

下游产品

(S)-tert-butyl-4-((18-((4R,5S)-5-((R)-6-(benzyloxy)-1-(methoxymethoxy)hexyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-16-oxooctadec-17-ynyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate