百科

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

CAS号：1354928-50-9

英文名：N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

分子式：C27H43ClN2O4S

分子量：527.159

合成路线

(2S,4'S,4a'S,5'R,6'R,8a'S)-5'-amino-4'-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6'-methyl-1-tosyloctahydro-2'H-spiro[aziridine-2,1'-naphthalen]-6'-ol

(2S,4'S,4a'S,5'R,6'R,8a'S)-5'-amino-4'-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6'-methyl-1-tosyloctahydro-2'H-spiro[aziridine-2,1'-naphthalen]-6'-ol

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

(1R,2R,4aS,8S,8aS)-1-azido-8-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyl-5-methylenedecahydronaphthalen-2-ol

(1R,2R,4aS,8S,8aS)-1-azido-8-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyl-5-methylenedecahydronaphthalen-2-ol

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

(1'S,4'S,4a'S,5'R,6'R,8a'S)-5'-azido-4'-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6'-methyl-1-tosyloctahydro-2'H-spiro[aziridine-2,1'-naphthalen]-6'-ol

(1'S,4'S,4a'S,5'R,6'R,8a'S)-5'-azido-4'-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6'-methyl-1-tosyloctahydro-2'H-spiro[aziridine-2,1'-naphthalen]-6'-ol

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

4-methyl-N-[(E)-phenyl-λ3-iodanylidene]benzenesulfonamide

4-methyl-N-[(E)-phenyl-λ3-iodanylidene]benzenesulfonamide

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

N-((1S,4S,4aS,5R,6R,8aS)-5-amino-4-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6-hydroxy-1,6-dimethyldecahydronaphthalen-1-yl)-4-methylbenzenesulfonamide

上游原料

(1R,2R,4aS,8S,8aS)-1-azido-8-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyl-5-methylenedecahydronaphthalen-2-ol 4-methyl-N-[(E)-phenyl-λ3-iodanylidene]benzenesulfonamide (1'S,4'S,4a'S,5'R,6'R,8a'S)-5'-azido-4'-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6'-methyl-1-tosyloctahydro-2'H-spiro[aziridine-2,1'-naphthalen]-6'-ol (2S,4'S,4a'S,5'R,6'R,8a'S)-5'-amino-4'-((2R,5S)-5-chloro-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)-6'-methyl-1-tosyloctahydro-2'H-spiro[aziridine-2,1'-naphthalen]-6'-ol

下游产品

(-)-10-epi-kalihinol I 5,10-bisformamidokalihinol A