百科

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

CAS号：1370008-36-8

英文名：((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

分子式：C13H18N6O6S

分子量：386.384

合成路线

5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

2-[(3aR,4R,6aS)-4-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]acetonitrile

2-[(3aR,4R,6aS)-4-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]acetonitrile

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

2-((3aS,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-3-(dimethylamino)acrylonitrile

2-((3aS,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-3-(dimethylamino)acrylonitrile

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

2-(2-((3aS,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanovinyl)hydrazinecarbothioamide

2-(2-((3aS,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanovinyl)hydrazinecarbothioamide

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

((3aR,4R,6S,6aS)-6-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

上游原料

2-(2-((3aS,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-cyanovinyl)hydrazinecarbothioamide 2-[(3aR,4R,6aS)-4-[(tert-butyl(diphenyl)silyl)oxymethyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]acetonitrile 5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose 2-((3aS,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-3-(dimethylamino)acrylonitrile

下游产品

((2R,3S,4R,5S)-5-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate