化合物简介
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling, respectively, and can penetrate the blood–brain barrier.
基本信息
中文名称
1-[4-(5'-氯-3,5-二甲基[2,4'-联吡啶]-2'-基)-1-哌嗪基]-3-(甲基磺酰基)-1-丙酮
英文名称
1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one
中文别名
英文别名
1-(4-(5\'-chloro-3,5-dimethyl-2,4\'-bipyridin-2\'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one、1-(4-(5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one、CS-1206、QC-1145
CAS号
1373615-35-0
分子式
C20H25ClN4O3S
分子量
436.956
精确质量
436.134
PSA
91.85
LOGP
3.5808
合成路线
