百科

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

CAS号：1422387-17-4

英文名：methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

分子式：C27H34N4O5

分子量：494.583

合成路线

(S)-methyl 3-amino-4-(2-(1-aminobut-3-enyl)pyridin-4-yl)phenylcarbamate

(S)-methyl 3-amino-4-(2-(1-aminobut-3-enyl)pyridin-4-yl)phenylcarbamate

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

(S,E)-N-((4-chloropyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

(S,E)-N-((4-chloropyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

(S)-N-((1S)-1-(4-chloropyridin-2-yl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide

(S)-N-((1S)-1-(4-chloropyridin-2-yl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

tert-butyl N-[(1S)-1-(4-chloropyridin-2-yl)but-3-en-1-yl]carbamate

tert-butyl N-[(1S)-1-(4-chloropyridin-2-yl)but-3-en-1-yl]carbamate

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

methyl N-(4-{2-[(1S)-1-{[(tert-butoxy)carbonyl]amino}but-3-en-1-yl]pyridin-4-yl}-3-((2R)-2-methylbut-3-enamido)phenyl)carbamate

上游原料

(S)-methyl 3-amino-4-(2-(1-aminobut-3-enyl)pyridin-4-yl)phenylcarbamate (S)-N-((1S)-1-(4-chloropyridin-2-yl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide tert-butyl N-[(1S)-1-(4-chloropyridin-2-yl)but-3-en-1-yl]carbamate

下游产品

methyl N-[(10R,14S)-14-amino-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02'7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate methyl N-[(10R)-14-{4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-2,5-dioxopiperazin-1-yl}-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate trifluoroacetate methyl N-[(10R,14S)-14-[2-chloro-N-({[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]carbamoyl}methyl)acetamido]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate (10R,14S)-5,14-diamino-10-methyl-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-9-one methyl (10R,14S)-5-amino-14-{[(tert-butoxy)carbonyl]amino}-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-4-carboxylate 2-oxopropyl N-[(10R,14S)-14-[1-(3-chloro-2-fluorophenyl)-5-methyl-1H-1,2,3-triazole-4-amido]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate methyl N-[(10R,14S)-14-[4-(3-chloro-2,6-difluorophenyl)-2,3-dioxopiperazin-1-yl]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate trifluoroacetate methyl N-[(10R,14S)-14-[({[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]carbamoyl}methyl)amino]-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate methyl N-[(10R)-14-{4-[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]-2,5-dioxopiperazin-1-yl}-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaen-5-yl]carbamate trifluoroacetate 1-(3-chloro-2-fluorophenyl)-N-[(10R,14S)-5-isothiocyanato-10-methyl-9-oxo-8,16-diazatricyclo[13.3.1.02,7]nonadeca-1(19),2(7),3,5,15,17-hexaene-14-yl]-5-methyl-1H-1,2,3-triazole-4-carboxamide