tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

CAS号：1422772-86-8

英文名：tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

分子式：C25H28FN7O4

分子量：509.533

合成路线

5-amino-2H-pyran-3(6H)-one

5-amino-2H-pyran-3(6H)-one

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

tert-butyl 5-amino-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-amino-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid methyl ester

2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid methyl ester

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

methyl 2-bromo-5-(pivaloyloxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate

methyl 2-bromo-5-(pivaloyloxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

methyl 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(pivaloyloxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate

methyl 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(pivaloyloxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-hydroxy-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-hydroxy-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

5-(tert-butoxycarbonylamino)tetrahydro-2H-pyran-3-yl methanesulfonate

5-(tert-butoxycarbonylamino)tetrahydro-2H-pyran-3-yl methanesulfonate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

tert-butyl 5-(2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamido)-tetrahydro-2H-pyran-3-ylcarbamate

上游原料

5-amino-2H-pyran-3(6H)-one 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid methyl 2-bromo-5-(pivaloyloxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid methyl ester methyl 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5-(pivaloyloxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butyl 5-hydroxy-tetrahydro-2H-pyran-3-ylcarbamate 5-(tert-butoxycarbonylamino)tetrahydro-2H-pyran-3-yl methanesulfonate tert-butyl 5-amino-tetrahydro-2H-pyran-3-ylcarbamate

下游产品

N-(5-aminotetrahydro-2H-pyran-3-yl)-2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide hydrochloride