百科

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

CAS号：1431873-82-3

英文名：ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

分子式：C26H26FN9O4S

分子量：579.606

合成路线

2-(chloromethyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

2-(chloromethyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

ethyl 3-fluoro-5-((3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)benzoate

ethyl 3-fluoro-5-((3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)benzoate

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6(5H)-one

3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6(5H)-one

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

6-chloro-3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazine

6-chloro-3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazine

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

3-bromo-6-chloropyrido[2,3-b]pyrazine

3-bromo-6-chloropyrido[2,3-b]pyrazine

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

3,6-dichloropyrido[2,3-b]pyrazine

3,6-dichloropyrido[2,3-b]pyrazine

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

ethyl 3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoate

上游原料

2-(chloromethyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide 3-bromo-6-chloropyrido[2,3-b]pyrazine ethyl 3-fluoro-5-((3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)benzoate 3,6-dichloropyrido[2,3-b]pyrazine 6-chloro-3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazine 3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6(5H)-one

下游产品

3-(((1-(N,N-dimethylsulfamoyl)-1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluorobenzoic acid 3-(((1H-imidazol-2-yl)methyl)(3-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-yl)amino)-5-fluoro-N-methylbenzamide