百科

tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

CAS号：1446139-31-6

英文名：tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

分子式：C43H50N6O5

分子量：730.894

合成路线

N-(3-(4-bromo-2-nitrophenyl)oxetan-3-yl)-2-methylpropane-2-sulfinamide

N-(3-(4-bromo-2-nitrophenyl)oxetan-3-yl)-2-methylpropane-2-sulfinamide

tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-((3-(4-bromo-2-nitrophenyl)oxetan-3-yl)carbamoyl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-((3-(4-bromo-2-nitrophenyl)oxetan-3-yl)carbamoyl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-((3-(2-amino-4-bromophenyl)oxetan-3-yl)carbamoyl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-((3-(2-amino-4-bromophenyl)oxetan-3-yl)carbamoyl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

tert-butyl (S)-2-(5-(4'-(2'-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-7'-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

上游原料

N-(3-(4-bromo-2-nitrophenyl)oxetan-3-yl)-2-methylpropane-2-sulfinamide tert-butyl (S)-2-((3-(4-bromo-2-nitrophenyl)oxetan-3-yl)carbamoyl)pyrrolidine-1-carboxylate tert-butyl (S)-2-((3-(2-amino-4-bromophenyl)oxetan-3-yl)carbamoyl)pyrrolidine-1-carboxylate

下游产品

methyl ((S)-1-((S)-2-(7'-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1'H-spiro[oxetane-3,4'-quinazolin]-2'-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate