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2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

CAS号：146885-94-1

英文名：2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

分子式：C25H36N2O9

分子量：508.561

合成路线

甲醇钠

(6aR,6bS,10aS)-5,9-Dioxo-6b,7,10,10a-tetrahydro-5H,6aH-8-oxa-4,9a-diaza-pentaleno[2,1-a]naphthalene-6,6-dicarboxylic acid di-tert-butyl ester

(6aR,6bS,10aS)-5,9-Dioxo-6b,7,10,10a-tetrahydro-5H,6aH-8-oxa-4,9a-diaza-pentaleno[2,1-a]naphthalene-6,6-dicarboxylic acid di-tert-butyl ester

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

(S)-3-{2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-3-yl]-ethyl}-4-vinyl-oxazolidin-2-one

(S)-3-{2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-3-yl]-ethyl}-4-vinyl-oxazolidin-2-one

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

2-{(S)-3-[2-(2-Formyl-pyridin-3-yl)-ethyl]-2-oxo-oxazolidin-4-ylmethylene}-malonic acid di-tert-butyl ester

2-{(S)-3-[2-(2-Formyl-pyridin-3-yl)-ethyl]-2-oxo-oxazolidin-4-ylmethylene}-malonic acid di-tert-butyl ester

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

2-((S)-3-{2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-3-yl]-ethyl}-2-oxo-oxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

2-((S)-3-{2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-3-yl]-ethyl}-2-oxo-oxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

2-[(2S,3R,4S)-2-Hydroxymethyl-1-methoxycarbonyl-4-(2-methoxycarbonyl-pyridin-3-yl)-pyrrolidin-3-yl]-malonic acid di-tert-butyl ester

上游原料

甲醇钠 2-{(S)-3-[2-(2-Formyl-pyridin-3-yl)-ethyl]-2-oxo-oxazolidin-4-ylmethylene}-malonic acid di-tert-butyl ester (S)-3-{2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-3-yl]-ethyl}-4-vinyl-oxazolidin-2-one 2-((S)-3-{2-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-3-yl]-ethyl}-2-oxo-oxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester (6aR,6bS,10aS)-5,9-Dioxo-6b,7,10,10a-tetrahydro-5H,6aH-8-oxa-4,9a-diaza-pentaleno[2,1-a]naphthalene-6,6-dicarboxylic acid di-tert-butyl ester

下游产品

(2S,3R,4S)-3-(Bis-tert-butoxycarbonyl-methyl)-4-(2-methoxycarbonyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrrolidine-1,2-dicarboxylic acid dimethyl ester