百科

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

CAS号：1620693-95-9

英文名：methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

分子式：C41H46BFN6O6S

分子量：780.715

合成路线

3-bromo-10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

3-bromo-10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

ethyl 5,6-dihydro-4H-cyclopenta[d]thiazole-2-carboxylate

ethyl 5,6-dihydro-4H-cyclopenta[d]thiazole-2-carboxylate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)methanol

(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)methanol

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

3-bromo-10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-12,12a-dihydro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

3-bromo-10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-12,12a-dihydro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

5-bromo-2-(5-chloro-1H-indol-2-yl)-3-fluorophenol

5-bromo-2-(5-chloro-1H-indol-2-yl)-3-fluorophenol

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

5-bromo-2-(5-chloroindolin-2-yl)-3-fluorophenol

5-bromo-2-(5-chloroindolin-2-yl)-3-fluorophenol

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((2S)-1-((2S)-2-(4-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-10-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

上游原料

ethyl 5,6-dihydro-4H-cyclopenta[d]thiazole-2-carboxylate 5-bromo-2-(5-chloro-1H-indol-2-yl)-3-fluorophenol 5-bromo-2-(5-chloroindolin-2-yl)-3-fluorophenol (5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)methanol 3-bromo-10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-12,12a-dihydro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole 3-bromo-10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole 10-chloro-6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

下游产品

tert-butyl (2S)-2-(5-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)-1-fluoro-3-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-10-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate