2-[(2R,3R,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-acetamide

2-[(2R,3R,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-acetamide

CAS号：186839-99-6

英文名：2-[(2R,3R,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-acetamide

分子式：C17H29N3O7Si

分子量：415.514

合成路线

3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

2-[(2R,3R,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-acetamide

2-[(2R,3R,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-acetamide

3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

2-[(2R,3R,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-acetamide

2-[(2R,3R,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-acetamide

上游原料

3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 3-Benzyloxymethyl-1-[(2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

下游产品

1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(carbamoylmethyl)-β-D-ribo-pentofuranosyl]cytosine [(2R,3R,4R,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-3-yl]-acetonitrile 1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(cyanomethyl)-β-D-ribo-pentofuranosyl]cytosine