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Epothilone D
CAS号:189453-10-9
英文名:epothilone D
分子式:C26H39NO5S
分子量:477.657
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合成路线
218614-13-2
(-)-甲基(3S)-3,5-二-{[叔-丁基二甲基硅烷基)氧基]}-2,2-二甲基戊酸酯
189453-10-9
Epothilone D
218614-07-4
4-((1E,3S,5Z)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-iodo-2,6-dimethylhepta-1,5-dienyl)-2-methyl-1,3-thiazole
189453-10-9
Epothilone D
76439-01-5
(3S)-2,2-dimethyl-3-hydroxycyclopentanone
189453-10-9
Epothilone D
736141-33-6
(S)-3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylcyclopentanone
189453-10-9
Epothilone D
1352079-84-5
189453-10-9
Epothilone D
1352079-85-6
(S)-tert-butyl((3-ethyl-2,2-dimethylcyclopent-3-en-1-yl)oxy)dimethylsilane
189453-10-9
Epothilone D
3883-58-7
2,2-二甲基环戊烷-1,3-二酮
189453-10-9
Epothilone D
396092-18-5
(2S)-5-methyl-4-(phenylsulfonyl)hex-5-ene-1,2-diol
189453-10-9
Epothilone D
331268-29-2
(3S)-3-(tert-butyldimethylsilyloxy)-4,4-dimethylheptane-1,5-diol
189453-10-9
Epothilone D
396092-19-6
(2S)-1-tert-butyldimethylsilyloxy-5-methyl-4-(phenylsulfonyl)hex-5-en-2-ol
189453-10-9
Epothilone D
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上游原料
(2E)-2-Methyl-3-(2-methyl-1,3-thiazol-4-yl)acrylaldehyde
(2S,6Z,9S,10E)-9-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-11-(2-methyl-1,3-thiazol-4-yl)undeca-6,10-dienal
(2S,3S,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptan-1-ol
2,2-Dimethyl-3-oxopentanal
(4S,7R,8S,9S,13Z,16S)-4,8-二-{[叔-丁基(二甲基)硅烷基]氧基}-5,5,7,9,13-五甲基-16-[(E)-1-甲基-2-(2-甲基-1,3-噻唑-4-基)乙烯基]氧代环己癸-13-烯-2,6-二酮
(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代-十七-12,16-二烯酸
(3R,4R,5S)-3-(2-(1,3-dithian-2-yl)propan-2-yl)-5-((S)-1-(benzyloxy)propan-2-yl)-4,7,7,8,8-pentamethyl-1,1,1-triphenyl-2,6-dioxa-1,7-disilanonane
(3R,4R,5S,6S)-6-((S)-1-(benzyloxy)propan-2-yl)-3-(iodomethyl)-2-methoxy-3,5-dimethyltetrahydro-2H-pyran-4-ol
(3S)-4-[7-bromo-3-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-hepta-1,5-dienyl]-2-methyl-thiazole
(1S)-[(1E)-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethynyl]-3-butenyl acetate
2-甲基-1,3-噻唑-4-甲醛
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-(4-methoxy-benzyloxy)-4,4,6,8-tetramethyl-5-oxo-nonanoic acid
(1E,5Z)-(S)-2,6-Dimethyl-1-(2-methyl-thiazol-4-yl)-octa-1,5,7-trien-3-ol
(3S,6R,7S,8S,12Z,15S,16E)-5-oxo-15-hydroxy-3-triethylsilanoxy-17-(2-methylthiazol-4-yl)-4,4,6,8,12,16-hexamethyl-7-(2,2,2-trichloroethoxycarbonyloxy)heptadeca-12,16-dienoic acid
(1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol
(1E,3Z)-1-甲氧基-2-甲基-3-(三甲基硅氧基)-1,3-戊二烯
tert-butyl 4,4-dimethyl-3,5-dioxoheptanoate
(5S)-2-iodo-6-methyl-7-(2-methylthiazol-4-yl)-5-(triethylsilyloxy)-2,6-heptadiene
(4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol
tert-butyl (6R,7S,8S,12Z,15S,16E)-3,5-dioxo-15-hydroxy-17-(2-methylthiazol-4-yl)-4,4,6,8,12,16-hexamethyl-(2,2,2-trichloroethoxycarbonyl)pentadeca-12,16-dieno-ate
(13Z,4S,7R,8S,9S,16S)-4-(tert-butyldimethylsilyloxy)-8-hydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]oxacyclohexadec-13-ene-2,6-dione
(2S,3S,4R,5R)-1-(benzyloxy)-6-(1,3-dithian-2-yl)-2,4,6-trimethyl-5-((triphenylsilyl)oxy)heptan-3-ol
(5S)-5-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyloct-7en-3-one
S-ethyl (2S,Z)-2-((tert-butyldimethylsilyl)oxy)-5-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)hex-4-enethioate
(3S,6R,7S,12Z,15S,16E)-3,7-二-{[叔-丁基(二甲基)硅烷基]氧基}-15-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代十七碳-12,16-二烯酸
(4S)-4-benzyl-3-((Z)-5-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)hex-4-enoyl)oxazolidin-2-one
10,11-didehydroepothilone D
(S)-4-Benzyl-3-[(Z)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-6-(tetrahydro-pyran-2-yloxy)-hex-4-enoyl]-oxazolidin-2-one
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-4,4,6,8-tetramethyl-5-oxo-nonanoic acid methyl ester
methyl (3S,6R,7S,8R)-3,7-bis((tert-butyldimethylsilyl)oxy)-4,4,6,8-tetramethyl-5,9-dioxononanoate
(3S)-2-methyl-1-(2-methyl-1,3-thiazol-4-yl)hexa-1,5-dien-3-ol
(-)-(2Z,5S,6E)-5-{[叔-丁基(二甲基)硅烷基]氧基}-2,6-二甲基-7-(2-甲基-1,3-噻唑-4-基)庚-2,6-二烯-1-醇
(Z)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-7-(tetrahydro-pyran-2-yloxy)-hept-5-en-2-one
(3S,6R,7S,8S)-3,7-bis((tert-butyldimethylsilyl)oxy)-9-((4-methoxybenzyl)oxy)-4,4,6,8-tetramethyl-5-oxononanal
12,13-deoxy-7-(2,2,2-trichloroethoxycarbonyl)-3-(triethylsilyloxy)epothilone B
(2R,3R,4R,5R)-3-((tert-butyldimethylsilyl)oxy)-6-(1,3-dithian-2-yl)-2,4,6-trimethyl-5-((triphenylsilyl)oxy)heptanal
(E)-9,10-dehydro-12,13-desoxyepothilone B
(2S,3S,4R,7S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-2,4,6,6-tetramethyl-dec-9-en-5-one
(4S,7R,8S,9S,16S)-4,8-bis((tert-butyldimethylsilyl)oxy)-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)oxacyclohexadec-13-ene-2,6-dione
(2S,3S,4R)-2-((S)-1-(benzyloxy)propan-2-yl)-3,5-dimethyl-3,4-dihydro-2H-pyran-4-ol
(2S,3S,4R,7S)-7-((tert-butyldimethylsilyl)oxy)-3-hydroxy-1-((4-methoxybenzyl)oxy)-2,4,6,6-tetramethyldec-9-en-5-one
tert-butyl (3S,6R,7S,8S,12Z,15S,16E)-5-oxo-3,15-dihydroxy-17-(2-methylthiazol-4-yl)-4,4,6,8,12,16-hexamethyl-(2,2,2-trichloroethoxycarbonyl)pentadeca-12,16-dienoate
4-((1E,3S,5Z)-3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-7-((tetrahydro-2H-pyran-2-yl)oxy)hepta-1,5-dien-1-yl)-2-methylthiazole
(4S,7R,8S,9S,16S,Z)-4-hydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-2,6-dioxooxacyclohexadec-13-en-8-yl (2,2,2-trichloroethyl) carbonate
[(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane
tert-Butyldimethylsilyl {(1S,3Z)-4-iodo-1-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-pentenyl} ether
tert-butyl (6R,7S,8S,12Z,15S,16E)-15-((tert-butyldimethylsilyl)oxy)-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-3,5-dioxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoate
下游产品
埃博霉素B