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(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

CAS号：194994-15-5

英文名：(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

分子式：C22H29N3O8S

分子量：495.546

合成路线

(3R,5S)-N-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxy-5-((R)-1,3-dihydroxypropyl)pyrrolidine

(3R,5S)-N-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxy-5-((R)-1,3-dihydroxypropyl)pyrrolidine

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

(2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-(2-ethoxycarbonyl-1-hydroxyethyl)pyrrolidine

(2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-(2-ethoxycarbonyl-1-hydroxyethyl)pyrrolidine

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

(2S,4R)-2-[(R)-3-(Allyloxycarbonyl-methyl-amino)-1-hydroxy-propyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-2-[(R)-3-(Allyloxycarbonyl-methyl-amino)-1-hydroxy-propyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

(2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-[1-hydroxy-3-(p-toluenesulfonyloxy)propyl]pyrrolidine

(2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-[1-hydroxy-3-(p-toluenesulfonyloxy)propyl]pyrrolidine

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

(2S,4S)-4-acetylthio-2-[1-hydroxy-3-(N-allyloxycarbonyl-N-methylamino)propyl]-N-(p-nitrobenzyloxycarbonyl)pyrrolidine

上游原料

(2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-[1-hydroxy-3-(p-toluenesulfonyloxy)propyl]pyrrolidine (3R,5S)-N-tert-butoxycarbonyl-3-tert-butyldimethylsilyloxy-5-((R)-1,3-dihydroxypropyl)pyrrolidine (2S,4R)-2-[(R)-3-(Allyloxycarbonyl-methyl-amino)-1-hydroxy-propyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-(2-ethoxycarbonyl-1-hydroxyethyl)pyrrolidine

下游产品

(2S,4S)-2-[3-(N,N-dimethylamino)-1-hydroxypropyl]-4-mercapto-N-(p-nitrobenzyloxycarbonyl)pyrrolidine (2S,4S)-2-[3-(N,N-dimethylamino)-1-hydroxypropyl]-N-(p-nitrobenzyloxycarbonyl)-4-tritylthiopyrrolidine