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{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

CAS号：209786-18-5

英文名：{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

分子式：C20H41NO6Si

分子量：419.628

合成路线

1-O-(tert-butyldimethylsilyl)oxy-2-tert-butylcarbonylamino-2-deoxy-3,4-O-isopropylidene-5,6-epoxy-D-mannitol

1-O-(tert-butyldimethylsilyl)oxy-2-tert-butylcarbonylamino-2-deoxy-3,4-O-isopropylidene-5,6-epoxy-D-mannitol

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

(S)-tert-Butoxycarbonylamino-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetic acid methyl ester

(S)-tert-Butoxycarbonylamino-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetic acid methyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

[(R)-1-((4R,5S)-2,2-Dimethyl-5-(R)-oxiranyl-[1,3]dioxolan-4-yl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

[(R)-1-((4R,5S)-2,2-Dimethyl-5-(R)-oxiranyl-[1,3]dioxolan-4-yl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

[(R)-2-Hydroxy-1-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-ethyl]-carbamic acid tert-butyl ester

[(R)-2-Hydroxy-1-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-ethyl]-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

1-O-acetyl-2-tert-butoxycarbonylamino-2-deoxy-3,4-O-isopropylidene-D-mannitol

1-O-acetyl-2-tert-butoxycarbonylamino-2-deoxy-3,4-O-isopropylidene-D-mannitol

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

1-O-acetyl-2-tert-butoxycarbonylamino-2-deoxy-3,4:5,6-di-O-isopropylidene-D-mannitol

1-O-acetyl-2-tert-butoxycarbonylamino-2-deoxy-3,4:5,6-di-O-isopropylidene-D-mannitol

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5R)-5-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

上游原料

1-O-(tert-butyldimethylsilyl)oxy-2-tert-butylcarbonylamino-2-deoxy-3,4-O-isopropylidene-5,6-epoxy-D-mannitol (S)-tert-Butoxycarbonylamino-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetic acid methyl ester [(R)-1-((4R,5S)-2,2-Dimethyl-5-(R)-oxiranyl-[1,3]dioxolan-4-yl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester [(R)-2-Hydroxy-1-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-ethyl]-carbamic acid tert-butyl ester 1-O-acetyl-2-tert-butoxycarbonylamino-2-deoxy-3,4:5,6-di-O-isopropylidene-D-mannitol 1-O-acetyl-2-tert-butoxycarbonylamino-2-deoxy-3,4-O-isopropylidene-D-mannitol

下游产品

(2R,3R,4R,5S)-3,4-dihydroxy-2-(hydroxymethyl)-5-methylpyrrolidine