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(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

CAS号：217488-47-6

英文名：(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

分子式：C21H38N2O5Si

分子量：426.622

合成路线

allyl 1-benzyl-3-oxo-4-piperidinecarboxylate

allyl 1-benzyl-3-oxo-4-piperidinecarboxylate

(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

1-Benzyl-4-{(2S,3S)-1-(tert-butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-piperidine-4-carboxylic acid allyl ester

1-Benzyl-4-{(2S,3S)-1-(tert-butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-piperidine-4-carboxylic acid allyl ester

(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(3S,4R)-4-[4-(allyloxycarbonyl)-1-benzyl-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(3S,4R)-4-[4-(allyloxycarbonyl)-1-benzyl-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(3R,4S)-4-[(R)-1-(tert-butoxycarbonyl)-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

上游原料

(3S,4R)-4-[4-(allyloxycarbonyl)-1-benzyl-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 1-Benzyl-4-{(2S,3S)-1-(tert-butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-piperidine-4-carboxylic acid allyl ester allyl 1-benzyl-3-oxo-4-piperidinecarboxylate

下游产品

allyl (8S,9R,10S)-5-methyl-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[[1-(allyloxycarbonyl)pyrrolidin-3-yl]thiocarbamoyl]-10-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-carbamoyl-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[2-[(allyloxycarbonyl-N-methyl)amino]acetyl]-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-allyloxycarbonyl-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[3-[[N,N'-bis(allyloxycarbonyl)amidino]amino]propionyl]-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[2-(allyloxycarbonylamino)acetyl]-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[N-(allyloxycarbonyl)acetimidoyl]-10-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-acetyl-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[[1-(allyloxycarbonyl)pyrrolidin-3-yl]carbamoyl]-10-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[3-(tert-butoxycarbonylamino)propionyl]-10-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[[1-(allyloxycarbonyl)pyrrolidin-3-yl]thiocarbamoyl]-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-(carbamoyl)methyl-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-10-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-5-methyl-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-(tert-butoxycarbonyl)-10-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate allyl (8S,9R,10S)-5-[[1-(allyloxycarbonyl)pyrrolidin-3-yl]carbamoyl]-10-[(R)-1-hydroxyethyl]-11-oxo-1,5-diazatricyclo[7.2.0.03,8]undec-2-ene-2-carboxylate