百科

1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

CAS号：219600-99-4

英文名：1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

分子式：C24H43N3O6Si2

分子量：525.786

合成路线

1-(3,5-di-O-benzyl-4-C-(hydroxymethyl)-β-D-ribofuranosyl)thymine

1-(3,5-di-O-benzyl-4-C-(hydroxymethyl)-β-D-ribofuranosyl)thymine

1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

1-(2-amino-2-N,4-C-methylene-2-N,3-O,5-O-tribenzyl-β-D-ribofuranosyl)thymine

1-(2-amino-2-N,4-C-methylene-2-N,3-O,5-O-tribenzyl-β-D-ribofuranosyl)thymine

1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

(1R,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

(1R,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

1-(2-methylamino-2-N,4-C-methylene-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl)thymine

上游原料

1-(3,5-di-O-benzyl-4-C-(hydroxymethyl)-β-D-ribofuranosyl)thymine (1R,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 1-(2-amino-2-N,4-C-methylene-2-N,3-O,5-O-tribenzyl-β-D-ribofuranosyl)thymine

下游产品

(1R,3R,4R,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-methyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane