百科

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

CAS号：219646-84-1

英文名：3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

分子式：C40H74Cl3N5O11Si2

分子量：963.572

合成路线

(3S,5R)-5-Hydroxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

(3S,5R)-5-Hydroxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

(3R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

(3R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

(S)-2-(9H-Fluoren-9-ylmethoxycarbonyloxy)-3-methyl-butyric acid allyl ester

(S)-2-(9H-Fluoren-9-ylmethoxycarbonyloxy)-3-methyl-butyric acid allyl ester

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

di-tert-butyl 1-((3R,5R)-5-(bromomethyl)-2-oxotetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

di-tert-butyl 1-((3R,5R)-5-(bromomethyl)-2-oxotetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

3-(tert-butyl-dimethyl-silanyloxy)-2-{2-[(5-(tert-butyl-dimethyl-silanyloxy)-2-{3-methyl-2-[3-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-butyryloxy]-butyryl}-hexahydro-pyridazine-3-carbonyl)-amino]-4-methyl-pentanoylamino}-butyric acid

上游原料

(3R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester (3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester di-tert-butyl 1-((3R,5R)-5-(bromomethyl)-2-oxotetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate (3S,5R)-5-Hydroxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester (S)-2-(9H-Fluoren-9-ylmethoxycarbonyloxy)-3-methyl-butyric acid allyl ester

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