{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

CAS号：226931-90-4

英文名：{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

分子式：C19H36N2O8

分子量：420.498

合成路线

1,6-di-O-benzyl-3,4-O-methylethylidene-L-iditol

1,6-di-O-benzyl-3,4-O-methylethylidene-L-iditol

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

2,5-diazido-1,6-di-O-benzyl-2,5-dideoxy-3,4-O-methylethylidene-D-mannitol

2,5-diazido-1,6-di-O-benzyl-2,5-dideoxy-3,4-O-methylethylidene-D-mannitol

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

1,6-di-O-benzyl-2,5-di-O-methanesulfonyl-3,4-O-methylethylidene-L-iditol

1,6-di-O-benzyl-2,5-di-O-methanesulfonyl-3,4-O-methylethylidene-L-iditol

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

3,4-O-methylethylidene-D-mannitol

3,4-O-methylethylidene-D-mannitol

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

{(R)-2-Benzyloxy-1-[(4R,5R)-5-((R)-2-benzyloxy-1-tert-butoxycarbonylamino-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-2-Benzyloxy-1-[(4R,5R)-5-((R)-2-benzyloxy-1-tert-butoxycarbonylamino-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

{(R)-1-[(4R,5R)-5-((R)-1-tert-Butoxycarbonylamino-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester

上游原料

1,6-di-O-benzyl-3,4-O-methylethylidene-L-iditol 1,6-di-O-benzyl-2,5-di-O-methanesulfonyl-3,4-O-methylethylidene-L-iditol {(R)-2-Benzyloxy-1-[(4R,5R)-5-((R)-2-benzyloxy-1-tert-butoxycarbonylamino-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-carbamic acid tert-butyl ester 2,5-diazido-1,6-di-O-benzyl-2,5-dideoxy-3,4-O-methylethylidene-D-mannitol 3,4-O-methylethylidene-D-mannitol

下游产品

(4S,4'S)-4,4'-((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(N-(tert-butyl)-4,5-dihydrothiazol-2-amine) (4S,4'S)-4,4'-((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(thiazolidine-2-thione)