百科

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

CAS号：251083-06-4

英文名：{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

分子式：C39H68O6S2Si

分子量：725.169

合成路线

(S)-4-benzyl-3-((2S,3S)-3-((tert-butyldimethylsilyl)oxy)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropanoyl)oxazolidin-2-one

(S)-4-benzyl-3-((2S,3S)-3-((tert-butyldimethylsilyl)oxy)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropanoyl)oxazolidin-2-one

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

2-((E)-(S)-3-Iodo-1-methyl-but-2-enyl)-[1,3]dithiane

2-((E)-(S)-3-Iodo-1-methyl-but-2-enyl)-[1,3]dithiane

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

(S)-2-(but-3-yn-2-yl)-1,3-dithiane

(S)-2-(but-3-yn-2-yl)-1,3-dithiane

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

上游原料

2-((E)-(S)-3-Iodo-1-methyl-but-2-enyl)-[1,3]dithiane (S)-4-benzyl-3-((2S,3S)-3-((tert-butyldimethylsilyl)oxy)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropanoyl)oxazolidin-2-one (S)-2-(but-3-yn-2-yl)-1,3-dithiane

下游产品

(E)-(3R,4S,5S,7R,8R,11S,15R,17R)-3-Hydroxy-17-((2E,5Z)-(1S,4S)-1-hydroxy-2,4-dimethyl-hepta-2,5-dienyl)-4-methoxy-5,7,9,11,15-pentamethyl-8-triisopropylsilanyloxy-oxacyclooctadec-9-ene-2,6,12,16-tetraone