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(3R,4S,6R)-1,1-diethoxy-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexane

(3R,4S,6R)-1,1-diethoxy-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexane

CAS号：288374-68-5

英文名：(3R,4S,6R)-1,1-diethoxy-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexane

分子式：C23H40O5Si

分子量：424.646

合成路线

(R)-(-)-N-methyl-N-methoxy(2-hydroxy-2-phenyl)acetamide

(R)-(-)-N-methyl-N-methoxy(2-hydroxy-2-phenyl)acetamide

(3R,4S,6R)-1,1-diethoxy-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexane

(3R,4S,6R)-1,1-diethoxy-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexane

(R)-(-)-N-methyl-N-methoxy(2-tert-butyldimethylsilyloxy-2-phenyl)acetamide

(R)-(-)-N-methyl-N-methoxy(2-tert-butyldimethylsilyloxy-2-phenyl)acetamide

(3R,4S,6R)-1,1-diethoxy-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexane

(3R,4S,6R)-1,1-diethoxy-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexane

上游原料

(R)-(-)-N-methyl-N-methoxy(2-tert-butyldimethylsilyloxy-2-phenyl)acetamide (R)-(-)-N-methyl-N-methoxy(2-hydroxy-2-phenyl)acetamide

下游产品

(E)-(5S,6S,7R,8R)-5-[(S)-2-((R)-3-tert-Butoxycarbonylamino-2-methyl-propionyloxy)-4-methyl-pentanoylamino]-8-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-6-methyl-8-phenyl-oct-2-enoic acid allyl ester allyl (5R,6S,8R)-5-hydroxy-6-methyl-7-oxo-8-[(tert-butyldimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate methyl (5R,6S,8R)-5-hydroxy-6-methyl-7-oxo-8-[(tert-butyl-dimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate (E)-(5S,6S,7R,8R)-5-Amino-8-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-6-methyl-8-phenyl-oct-2-enoic acid allyl ester cryptophycin 226 allyl (5R,6S,7R,8R)-5-azido-6-methyl-7-hydroxy-8-[(tert-butyldimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate 2-[5-[2-(3-tert-butoxycarbonylamino-2-methyl-propionyloxy)-4-methyl-pentanoylamino]-8-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-6-methyl-8-phenyl-oct-2-enoylamino]-3-(3-chloro-4-methoxy-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester methyl (5R,6S,7R,8R)-5,7-dihydroxy-6-methyl-8-[(tert-butyldimethylsilyl)oxy]-8-phenyloct-2(E)-enoate (3R,4S,6R)-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexanal (E)-(5S,6S,7R,8R)-5-[(S)-2-((R)-3-tert-Butoxycarbonylamino-2-methyl-propionyloxy)-4-methyl-pentanoylamino]-8-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-6-methyl-8-phenyl-oct-2-enoic acid allyl (5R,6R,7R,8R)-5-tosyloxy-6-methyl-7-hydroxy-8-[(tert-butyldimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate allyl (5R,6S,8R)-5-tosyloxy-6-methyl-7-oxo-8-[(tert-butyldimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate methyl (5R,6R,7R,8R)-5-tosyloxy-6-methyl-7-hydroxy-8-[(tert-butyl-dimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate methyl (5R,6S,8R)-5-tosyloxy-6-methyl-7-oxo-8-[(tert-butyl-dimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate