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(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

CAS号：296250-75-4

英文名：(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

分子式：C40H50N2O9Si

分子量：730.918

合成路线

(2S,3S,4S)-3,4-dihydroxy-4-hydroxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4S)-3,4-dihydroxy-4-hydroxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2R,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-formyl-4-hydroxytetrahydrofuran

(2R,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-formyl-4-hydroxytetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

methyl 3,5-di-O-benzyl-4-C-methylsulfonyloxymethyl-α,β-D-ribofuranoside

methyl 3,5-di-O-benzyl-4-C-methylsulfonyloxymethyl-α,β-D-ribofuranoside

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(1S,3RS,4R,7S)-7-benzyloxy-1-benzyloxymethyl-3-methoxy-2,5-dioxabicyclo[2.2.1]heptane

(1S,3RS,4R,7S)-7-benzyloxy-1-benzyloxymethyl-3-methoxy-2,5-dioxabicyclo[2.2.1]heptane

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-hydroxymethyl-4-hydroxytetrahydrofuran

(2S,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-hydroxymethyl-4-hydroxytetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-(p-toluenesulfonyl)oxymethyl-4-hydroxytetrahydrofuran

(2S,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-(p-toluenesulfonyl)oxymethyl-4-hydroxytetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4S)-4-acetoxy-3-benzyloxy-4-benzyloxymethyl-2-((p-toluenesulfonyl)oxymethyl)tetrahydrofuran

(2S,3S,4S)-4-acetoxy-3-benzyloxy-4-benzyloxymethyl-2-((p-toluenesulfonyl)oxymethyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4S)-4-acetoxy-3-benzyloxy-4-benzyloxymethyl-2-(thymin-1-ylmethyl)tetrahydrofuran

(2S,3S,4S)-4-acetoxy-3-benzyloxy-4-benzyloxymethyl-2-(thymin-1-ylmethyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxymethyl-3,4-dihydroxy-2-(thymin-1-ylmethyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxymethyl-3,4-dihydroxy-2-(thymin-1-ylmethyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-3,4-dihydroxy-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-3,4-dihydroxy-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

(2S,3S,4R)-4-acetoxy-3-(tert-butyldimethylsilyloxy)-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran

上游原料

(2S,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-(p-toluenesulfonyl)oxymethyl-4-hydroxytetrahydrofuran (2S,3S,4S)-4-acetoxy-3-benzyloxy-4-benzyloxymethyl-2-(thymin-1-ylmethyl)tetrahydrofuran methyl 3,5-di-O-benzyl-4-C-methylsulfonyloxymethyl-α,β-D-ribofuranoside (2S,3S,4R)-3,4-dihydroxy-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran (2S,3S,4S)-3,4-dihydroxy-4-hydroxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran (2S,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-hydroxymethyl-4-hydroxytetrahydrofuran (2S,3S,4R)-4-acetoxymethyl-3,4-dihydroxy-2-(thymin-1-ylmethyl)tetrahydrofuran (2R,3S,4S)-3-benzyloxy-4-benzyloxymethyl-2-formyl-4-hydroxytetrahydrofuran (2S,3S,4S)-4-acetoxy-3-benzyloxy-4-benzyloxymethyl-2-((p-toluenesulfonyl)oxymethyl)tetrahydrofuran (1S,3RS,4R,7S)-7-benzyloxy-1-benzyloxymethyl-3-methoxy-2,5-dioxabicyclo[2.2.1]heptane

下游产品

(2S,3S,4R)-4-acetoxy-3-hydroxy-4-(4,4'-dimethoxytrityl)oxymethyl-2-((thymin-1-yl)methyl)tetrahydrofuran