化合物简介
HT-2157 (former code name SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.
基本信息
中文名称
1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one
英文名称
1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one
中文别名
英文别名
1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-1,3-dihydro-2H-indol-2-one、1-phenyl-3-[[3-(trifluoromethyl)-phenol]-imino]-1H-indol-2-one、1,3-dihydro-1-phenyl-3-[[3-trifluoromethylphenyl]imino]-2H-indol-2-one、1-phenyl-3-{[3-(trifluoromethyl)phenyl]azamethylene}benzo[d]azolidin-2-one
CAS号
303149-14-6
分子式
C21H13F3N2O
分子量
366.336
精确质量
366.098
PSA
32.67
LOGP
5.5695
合成路线
