百科

(R)-1-[(4R,5S)-5-((S)-2,2-Difluoro-1-hydroxy-but-3-enyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethane-1,2-diol

(R)-1-[(4R,5S)-5-((S)-2,2-Difluoro-1-hydroxy-but-3-enyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethane-1,2-diol

CAS号：321690-55-5

英文名：(R)-1-[(4R,5S)-5-((S)-2,2-Difluoro-1-hydroxy-but-3-enyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethane-1,2-diol

分子式：C11H18F2O5

分子量：268.254

合成路线

5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

(R)-1-[(4R,5S)-5-((S)-2,2-Difluoro-1-hydroxy-but-3-enyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethane-1,2-diol

(R)-1-[(4R,5S)-5-((S)-2,2-Difluoro-1-hydroxy-but-3-enyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethane-1,2-diol

(S)-1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2,2-difluoro-but-3-en-1-ol

(S)-1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2,2-difluoro-but-3-en-1-ol

(R)-1-[(4R,5S)-5-((S)-2,2-Difluoro-1-hydroxy-but-3-enyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethane-1,2-diol

(R)-1-[(4R,5S)-5-((S)-2,2-Difluoro-1-hydroxy-but-3-enyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-ethane-1,2-diol

上游原料

(S)-1-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2,2-difluoro-but-3-en-1-ol 5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

下游产品

(3aS,5S,5aS,8aR,8bS)-4,4-Difluoro-1,7,7-trimethyl-octahydro-2,6,8-trioxa-1-aza-as-indacen-5-ol Acetic acid (3aS,5S,5aR,8aR,8bS)-4,4-difluoro-1,7,7-trimethyl-octahydro-2,6,8-trioxa-1-aza-as-indacen-5-yl ester