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(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

CAS号：326853-63-8

英文名：(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

分子式：C13H20ClNO2

分子量：257.756

合成路线

tert-Butyl-dimethyl-[(R)-1-((2S,7R)-(S)-7-oxiranyl-2,3,6,7-tetrahydro-oxepin-2-yl)-propoxy]-silane

tert-Butyl-dimethyl-[(R)-1-((2S,7R)-(S)-7-oxiranyl-2,3,6,7-tetrahydro-oxepin-2-yl)-propoxy]-silane

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(4S,5S)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane

(4S,5S)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-{(2R,7S)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2,3,6,7-tetrahydro-oxepin-2-yl}-4-chloro-butyronitrile

(R)-4-{(2R,7S)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2,3,6,7-tetrahydro-oxepin-2-yl}-4-chloro-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(2S,3S)-2,3-dihydroxy-1-tosyloxypentane

(2S,3S)-2,3-dihydroxy-1-tosyloxypentane

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-1-((2S,7R)-(S)-7-Oxiranyl-2,3,6,7-tetrahydro-oxepin-2-yl)-propan-1-ol

(R)-1-((2S,7R)-(S)-7-Oxiranyl-2,3,6,7-tetrahydro-oxepin-2-yl)-propan-1-ol

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(S)-4-{(2R,7S)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2,3,6,7-tetrahydro-oxepin-2-yl}-4-hydroxy-butyronitrile

(S)-4-{(2R,7S)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2,3,6,7-tetrahydro-oxepin-2-yl}-4-hydroxy-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-hydroxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-hydroxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-1-acetoxy-2-benzyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-1-acetoxy-2-benzyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

(R)-4-Chloro-4-[(2R,7S)-7-((R)-1-hydroxy-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-butyronitrile

上游原料

(2S,3S)-2,3-dihydroxy-1-tosyloxypentane tert-Butyl-dimethyl-[(R)-1-((2S,7R)-(S)-7-oxiranyl-2,3,6,7-tetrahydro-oxepin-2-yl)-propoxy]-silane Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester (S)-4-{(2R,7S)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2,3,6,7-tetrahydro-oxepin-2-yl}-4-hydroxy-butyronitrile (R)-4-{(2R,7S)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2,3,6,7-tetrahydro-oxepin-2-yl}-4-chloro-butyronitrile 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-1-acetoxy-2-benzyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-hydroxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester (4S,5S)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester (R)-1-((2S,7R)-(S)-7-Oxiranyl-2,3,6,7-tetrahydro-oxepin-2-yl)-propan-1-ol

下游产品

(2S,7R)-2-[(1S)-1-bromopropyl]-7-[(1R)-chloro-4-hydroxybutyl]-2,3,6,7-tetrahydrooxepin (R)-4-[(2R,7S)-7-((S)-1-Bromo-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-4-chloro-butyronitrile (R)-4-[(2R,7S)-7-((S)-1-Bromo-propyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-4-chloro-butyraldehyde