百科

(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

CAS号：331728-62-2

英文名：(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

分子式：C24H28ClN9O6

分子量：573.989

合成路线

Trifluoro-methanesulfonic acid (3aR,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

Trifluoro-methanesulfonic acid (3aR,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

(2S,3S,4R,5R)-3-azido-5-(6-chloro-purin-9-yl)-4-acetoxy-tetrahydro-furan-2-carboxylic acid methylamide

(2S,3S,4R,5R)-3-azido-5-(6-chloro-purin-9-yl)-4-acetoxy-tetrahydro-furan-2-carboxylic acid methylamide

(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

2-cyano-4-chlorophenoxyacetic acid tert-butyl ester

2-cyano-4-chlorophenoxyacetic acid tert-butyl ester

(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

(2R,3R,4S,5S)(2-{[9-(4-azido-3-hydroxy-5-methylcarbamoyl-tetrahydrofuran-2-yl)-9H-purin-6-ylamino]-methyl}-4-chlorophenoxy)acetic acid tert-butyl ester

上游原料

2-cyano-4-chlorophenoxyacetic acid tert-butyl ester Trifluoro-methanesulfonic acid (3aR,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester (2S,3S,4R,5R)-3-azido-5-(6-chloro-purin-9-yl)-4-acetoxy-tetrahydro-furan-2-carboxylic acid methylamide

下游产品

(2S,3S,4R,5R)3-azido-5-{6-[5-chloro-2-(2-oxo-2-piperazin-1-yl-ethoxy)-benzylamino]-purin-9-yl}-4-hydroxy-tetrahydro-furan-2-carboxylic acid methylamide