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1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

CAS号：335160-93-5

英文名：1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

分子式：C27H28FN5O3

分子量：489.541

合成路线

(S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

(S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(S),5(S)-1-benzyl-8-tert-butoxycarbonyl-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(S),5(S)-1-benzyl-8-tert-butoxycarbonyl-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

(1S)-tert-butyl-1-{[(2,4-dimethoxybenzyl)amino]methyl}but-3-enylcarbamate

(1S)-tert-butyl-1-{[(2,4-dimethoxybenzyl)amino]methyl}but-3-enylcarbamate

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-[2-(phenylsulfonyloxy)ethyl]-2-piperazinone

5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-[2-(phenylsulfonyloxy)ethyl]-2-piperazinone

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

(1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-hydroxyethyl)-2-piperazinone

5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-hydroxyethyl)-2-piperazinone

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane

上游原料

5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-hydroxyethyl)-2-piperazinone (1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate 5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-[2-(phenylsulfonyloxy)ethyl]-2-piperazinone (S)-5-allyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-2-piperazinone 1(S),5(S)-1-benzyl-8-tert-butoxycarbonyl-3-(2,4-dimethoxybenzyl)-3,8-diaza-2-oxobicyclo[3.2.1]octane 5(S),3(S)-3-benzyl-4-tert-butoxycarbonyl-1-(2,4-dimethoxybenzyl)-5-(2-oxoethyl)-2-piperazinone (1S)-tert-butyl-1-{[(2,4-dimethoxybenzyl)amino]methyl}but-3-enylcarbamate

下游产品

1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane 1(R),5(S)-8-[1-(4-cyano-3-fluorobenzyl)-5-imidazolylmethyl]-3-[2-chloro-5-(methanesulfonyloxy)benzyl]-3,8-diaza-2-oxobicyclo[3.2.1]octane