化合物简介
Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
基本信息
中文名称
N-羟基-N'-3-吡啶基辛二酰胺
英文名称
N'-hydroxy-N-pyridin-3-yloctanediamide
中文别名
N-羟基-N\'-3-吡啶基辛烷二酰胺
英文别名
pyroxamide、N1-Hydroxy-N8-3-pyridinyl-octanediamide、N-Hydroxy-N\'-3-pyridinyloctanediamide
CAS号
382180-17-8
分子式
C13H19N3O3
分子量
265.308
精确质量
265.143
PSA
91.32
LOGP
2.33
编号系统
MDL号
MFCD13194970
物化性质
密度
1.215 g/cm3
折射率
1.569
安全信息
海关编码
2933399090
危险标志
GHS07
信号词
Warning
危险性描述
H302
合成路线
海关数据
共找到8个国家海关数据 >