百科

16,16-二甲基前列腺素 E2

16,16-二甲基前列腺素 E2

CAS号：39746-25-3

英文名：16,16-Dimethylprostaglandin E2

分子式：C22H36O5

分子量：380.518

合成路线

methyl (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoate

methyl (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoate

16,16-二甲基前列腺素 E2

16,16-二甲基前列腺素 E2

(R)-4,4-dimethyl-1-iodo-1(E)-octen-3-ol

(R)-4,4-dimethyl-1-iodo-1(E)-octen-3-ol

16,16-二甲基前列腺素 E2

16,16-二甲基前列腺素 E2

(R,E)-((1-iodo-4,4-dimethyloct-1-en-3-yl)oxy)trimethylsilane

(R,E)-((1-iodo-4,4-dimethyloct-1-en-3-yl)oxy)trimethylsilane

16,16-二甲基前列腺素 E2

16,16-二甲基前列腺素 E2

methyl (Z)-7-((1R,2R,3S)-2-((S,E)-4,4-dimethyl-3-((trimethylsilyl)oxy)oct-1-en-1-yl)-5-oxo-3-((trimethylsilyl)oxy)cyclopentyl)hept-5-enoate

methyl (Z)-7-((1R,2R,3S)-2-((S,E)-4,4-dimethyl-3-((trimethylsilyl)oxy)oct-1-en-1-yl)-5-oxo-3-((trimethylsilyl)oxy)cyclopentyl)hept-5-enoate

16,16-二甲基前列腺素 E2

16,16-二甲基前列腺素 E2

上游原料

(R,E)-((1-iodo-4,4-dimethyloct-1-en-3-yl)oxy)trimethylsilane methyl (Z)-7-((1R,2R,3S)-2-((S,E)-4,4-dimethyl-3-((trimethylsilyl)oxy)oct-1-en-1-yl)-5-oxo-3-((trimethylsilyl)oxy)cyclopentyl)hept-5-enoate (R)-4,4-dimethyl-1-iodo-1(E)-octen-3-ol methyl (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoate

下游产品

(5Z,13E,15R)-15-羟基-16,16-二甲基-9-氧代前列腺-5,10,13-三烯-1-酸