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2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

CAS号：460348-38-3

英文名：2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

分子式：C31H40O9

分子量：556.644

合成路线

tert-Butyl-((R)-4-iodo-1-methyl-but-3-ynyloxy)-dimethyl-silane

tert-Butyl-((R)-4-iodo-1-methyl-but-3-ynyloxy)-dimethyl-silane

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

(Z)-(R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5S)-2,2-dimethyl-5-(3-trimethylsilanyl-prop-2-ynyl)-[1,3]dioxolan-4-yl]-hex-2-en-1-ol

(Z)-(R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5S)-2,2-dimethyl-5-(3-trimethylsilanyl-prop-2-ynyl)-[1,3]dioxolan-4-yl]-hex-2-en-1-ol

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

(R)-5-(trimethylsilyl)pent-4-yn-2-ol

(R)-5-(trimethylsilyl)pent-4-yn-2-ol

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

(R)-tert-butyldimethyl(pent-4-yn-2-yloxy)silane

(R)-tert-butyldimethyl(pent-4-yn-2-yloxy)silane

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

2-Hydroxy-6-((E)-3-{(4S,5S)-5-[(Z)-(R)-5-hydroxy-1-(4-methoxy-benzyloxy)-hex-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-propenyl)-4-methoxy-benzoic acid methyl ester

上游原料

(R)-tert-butyldimethyl(pent-4-yn-2-yloxy)silane tert-Butyl-((R)-4-iodo-1-methyl-but-3-ynyloxy)-dimethyl-silane (Z)-(R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(4R,5S)-2,2-dimethyl-5-(3-trimethylsilanyl-prop-2-ynyl)-[1,3]dioxolan-4-yl]-hex-2-en-1-ol (R)-5-(trimethylsilyl)pent-4-yn-2-ol

下游产品

寄端霉素 (2E,11Z)-(5S,9S,14S)-18-Hydroxy-20-methoxy-10-(4-methoxy-benzyloxy)-7,7,14-trimethyl-6,8,15-trioxa-tricyclo[15.4.0.05,9]henicosa-1(21),2,11,17,19-pentaen-16-one