百科

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

CAS号：470699-83-3

英文名：5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

分子式：C32H38BrN3O7S

分子量：688.629

合成路线

2-(2-bromophenyl)-2-methylpropanol

2-(2-bromophenyl)-2-methylpropanol

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

(2R,3S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-carboxylic acid methyl ester

(2R,3S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-carboxylic acid methyl ester

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

S-2-(2-bromophenyl)-2-methylpropyl thioacetate

S-2-(2-bromophenyl)-2-methylpropyl thioacetate

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

上游原料

S-2-(2-bromophenyl)-2-methylpropyl thioacetate 5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine 2-(2-bromophenyl)-2-methylpropanol (2R,3S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-carboxylic acid methyl ester

下游产品

5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxy-3'-O-diethylphosphorylcytidine