(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

CAS号：475291-33-9

英文名：(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

分子式：C20H26Cl3NO8

分子量：514.781

合成路线

N-[(R)-1-benzyloxy-2-{(1R,5R,7R,8S)-3,3-dimethyl-8-methoxymethoxy-2,4,6-trioxabicyclo[3.3.0]octane-7-yl}but-3-en-2-yl]trichloroacetamide

N-[(R)-1-benzyloxy-2-{(1R,5R,7R,8S)-3,3-dimethyl-8-methoxymethoxy-2,4,6-trioxabicyclo[3.3.0]octane-7-yl}but-3-en-2-yl]trichloroacetamide

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

(Z)-4-benzyloxy-3-{(1R,5R,7R,8S)-8-methoxymethoxy-3,3-dimethyl-2,4,6-trioxabicyclo[3.3.0]oct-7-yl}but-2-en-1-ol

(Z)-4-benzyloxy-3-{(1R,5R,7R,8S)-8-methoxymethoxy-3,3-dimethyl-2,4,6-trioxabicyclo[3.3.0]oct-7-yl}but-2-en-1-ol

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

N-[(R)-2-Benzyloxy-1-formyl-1-((3aR,5R,6S,6aR)-6-methoxymethoxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-2,2,2-trichloro-acetamide

N-[(R)-2-Benzyloxy-1-formyl-1-((3aR,5R,6S,6aR)-6-methoxymethoxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-2,2,2-trichloro-acetamide

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

N-[(R)-2-Benzyloxy-1-hydroxymethyl-1-((3aR,5R,6S,6aR)-6-methoxymethoxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-2,2,2-trichloro-acetamide

N-[(R)-2-Benzyloxy-1-hydroxymethyl-1-((3aR,5R,6S,6aR)-6-methoxymethoxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-2,2,2-trichloro-acetamide

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

(E)-(4S,5R,6R,7R)-8-Benzyloxy-4,5,6-trihydroxy-7-hydroxymethyl-7-(2,2,2-trichloro-acetylamino)-oct-2-enoic acid ethyl ester

上游原料

N-[(R)-2-Benzyloxy-1-formyl-1-((3aR,5R,6S,6aR)-6-methoxymethoxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-2,2,2-trichloro-acetamide N-[(R)-2-Benzyloxy-1-hydroxymethyl-1-((3aR,5R,6S,6aR)-6-methoxymethoxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl]-2,2,2-trichloro-acetamide (Z)-4-benzyloxy-3-{(1R,5R,7R,8S)-8-methoxymethoxy-3,3-dimethyl-2,4,6-trioxabicyclo[3.3.0]oct-7-yl}but-2-en-1-ol N-[(R)-1-benzyloxy-2-{(1R,5R,7R,8S)-3,3-dimethyl-8-methoxymethoxy-2,4,6-trioxabicyclo[3.3.0]octane-7-yl}but-3-en-2-yl]trichloroacetamide

下游产品

tert-butyl N-[(E,2S,3R,4R,5S)-2-benzyloxymethyl-8-hydroxy-1,3:4,5-bis(isopropylidenedioxy)oct-6-en-2-yl]carbamate tert-butyl N-[(E,2S,3R,4R,5S)-2-benzyloxymethyl-8-bromo-1,3:4,5-bis(isopropylidenedioxy)oct-6-en-2-yl]carbamate (4R,5S)-5-tert-Butoxycarbonylamino-4-{(4R,5S)-5-[(E)-8-(2-hexyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2,2-dimethyl-[1,3]dioxane-5-carboxylic acid ((4R,5S)-4-{(4R,5S)-5-[(E)-8-(2-Hexyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxan-5-yl)-carbamic acid tert-butyl ester