百科

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

CAS号：476210-02-3

英文名：1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

分子式：C31H33FN2O3SSeSi

分子量：639.714

合成路线

4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

(2S,4S)-(+)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone

(2S,4S)-(+)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

145887-11-2

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester

5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

(3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-3-phenylselanyl-dihydro-thiophen-2-one

(3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-3-phenylselanyl-dihydro-thiophen-2-one

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

1-[(1R,2R,4S)-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-2-phenylselanyl-4-thio-β-D-pentofuranosyl]uracil

上游原料

(2S,4S)-(+)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone (2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester 5-(tert-butyldiphenylsilyloxy)-2-fluoro-4-iodopentanoic acid methyl ester (3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-3-phenylselanyl-dihydro-thiophen-2-one 4-(acetylsulfanyl)-5-(tert-butyldiphenylsilyloxy)-2-fluoropentanoic acid methyl ester

下游产品

1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,3-didehydro-2-fluoro-4-thio-β-D-ribofuranosyl]uracil