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雷帕霉素
CAS号:53123-88-9
英文名:sirolimus
分子式:C51H79NO13
分子量:914.172
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上游原料
164592-68-1
(2R,5S,7S,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,8-dimethyl-11-(trimethylsilyl)undec-8-en-10-yn-1-ol
186417-33-4
((S,Z)-5-methoxy-4-methyl-6-((2R,3R,7S,10R)-2,3,10-trimethyl-1,4,6-trioxaspiro[4.5]decan-7-yl)hex-3-en-1-yn-1-yl)trimethylsilane
186417-37-8
(2S)-methyl 1-((4R,7S,9S,E)-7-((tert-butyldimethylsilyl)oxy)-3-hydroxy-9-methoxy-4,10-dimethyl-13-(trimethylsilyl)tridec-10-en-12-ynoyl)piperidine-2-carboxylate
157837-56-4
(E)-(S)-3-Methyl-6-trimethylsilanyl-1-((2R,3R,7S,10R)-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-hex-3-en-5-yn-2-ol
930803-38-6
(2S,3R)-4-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-1-(2-((2R,5R,6S,7R,8R,10S,E)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethyl-5-((triethylsilyl)oxy)undec-3-en-2-yl)-1,3-dithian-2-yl)-3-methylbutan-2-ol
164592-83-0
(2S,3R)-1-(2-((2R,5R,6R,E)-5-((tert-butyldimethylsilyl)oxy)-6-methoxy-4-methyl-6-(2-((2R,4S)-4-methylhex-5-yn-2-yl)-1,3-dithian-2-yl)hex-3-en-2-yl)-1,3-dithian-2-yl)-4-((1S,3R,4R)-3-methoxy-4-((triisopropylsilyl)oxy)cyclohexyl)-3-methylbutan-2-ol
930803-57-9
(2R,3S,6R,9R,10S,11R,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-3-hydroxy-10-methoxy-11,15-bis((4-methoxybenzyl)oxy)-2,6,8,12,14-pentamethyl-9-((triethylsilyl)oxy)pentadec-7-en-5-one
164592-72-7
(S)-methyl 1-((4R,7S,9S,E)-7-((tert-butyldimethylsilyl)oxy)-9-methoxy-4,10-dimethyl-2,3-dioxo-13-(trimethylsilyl)tridec-10-en-12-ynoyl)piperidine-2-carboxylate
930803-61-5
930803-42-2
(S)-4-((2S,5R,6S)-6-((tert-butyldimethylsilyl)oxy)-5-methyltetrahydro-2H-pyran-2-yl)-3-methoxybutan-2-one
186417-21-0
(Z)-3-methyl-1-((2R,3R,7S,10R)-2,3,10-trimethyl-1,4,6-trioxaspiro[4.5]decan-7-yl)-6-(trimethylsilyl)hex-3-en-5-yn-2-one
186417-40-3
(Z)-(2R,5S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-methoxy-2,8-dimethyl-11-trimethylsilanyl-undec-8-en-10-yn-1-ol
155589-15-4
rapamycin 42-hemisuccinate methyl ester
186417-44-7
(S)-1-[(Z)-(4R,7S,9S)-7-(tert-Butyl-dimethyl-silanyloxy)-9-methoxy-4,10-dimethyl-2,3-dioxo-13-trimethylsilanyl-tridec-10-en-12-ynoyl]-piperidine-2-carboxylic acid methyl ester
18292-02-9
1-trimethylsilyl-1,3-pentadiyne
765915-17-1
(2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentan-1-ol
930803-23-9
(R,E)-2-(4-bromopent-3-en-2-yl)-1,3-dithiane
930803-27-3
(R,E)-2-(4,5-dibromopent-3-en-2-yl)-1,3-dithiane
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上游原料
(3S,5R,6R)-3-((1S,2R,4S)-1-hydroxy-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentyl)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-one
31-(trimethylsilylether)rapamycin
二甲基氯氧化磷
(S)-1-Boc-哌啶-2-羧酸
(2R,5R,6R,7R,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-ol
(2S,3R)-4-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-1-(2-((2R,5R,6S,7R,8R,10S,E)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethyl-5-((triethylsilyl)oxy)undec-3-en-2-yl)-1,3-dithian-2-yl)-3-methylbutan-2-ol
(2R,3S,6R,9R,10S,11R,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-3-hydroxy-10-methoxy-11,15-bis((4-methoxybenzyl)oxy)-2,6,8,12,14-pentamethyl-9-((triethylsilyl)oxy)pentadec-7-en-5-one
(S)-4-((2S,5R,6S)-6-((tert-butyldimethylsilyl)oxy)-5-methyltetrahydro-2H-pyran-2-yl)-3-methoxybutan-2-one
(S,E)-5-((2S,5R,6R)-6-hydroxy-5-methyltetrahydro-2H-pyran-2-yl)-4-methoxy-3-methylpent-2-enal
(S,E)-4-methoxy-3-methyl-5-((2S,5R)-5-methyl-6-oxotetrahydro-2H-pyran-2-yl)pent-2-enal
methyl (R,E)-2-bromo-4-(1,3-dithian-2-yl)pent-2-enoate
(R,E)-2-(4-bromopent-3-en-2-yl)-1,3-dithiane
(R,E)-2-(4,5-dibromopent-3-en-2-yl)-1,3-dithiane
(2R,4S)-2,4-dimethylpentane-1,5-diol
(3S,5R,6R)-3-((1S,2R,4S)-1,5-bis((4-methoxybenzyl)oxy)-2,4-dimethylpentyl)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-one
(2R,4S)-5-(4-methoxybenzyloxy)-2,4-dimethylpentanal
1-(tert-butyl) 2-((2R,3S,6R,9R,10R,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-10-methoxy-2,6,8,12,14-pentamethyl-5,11,15-trioxo-9-((triethylsilyl)oxy)pentadec-7-en-3-yl) (S)-piperidine-1,2-dicarboxylate
(((2R,5R,6S,7R,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-yl)oxy)triethylsilane
(2R,5R,6R,7S,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-ol
(((2R,5R,6S,7S,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-yl)oxy)triethylsilane
(2R,3S,6R,9R,10S,11S,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-3-hydroxy-10-methoxy-11,15-bis((4-methoxybenzyl)oxy)-2,6,8,12,14-pentamethyl-9-((triethylsilyl)oxy)pentadec-7-en-5-one
(((2S,3R,6S)-6-((S)-3-(benzyloxy)-2-methoxypropyl)-3-methyltetrahydro-2H-pyran-2-yl)oxy)(tert-butyl)dimethylsilane
1-(tert-butyl) 2-((2R,3S,6R,9R,10S,11S,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-11,15-dihydroxy-10-methoxy-2,6,8,12,14-pentamethyl-5-oxo-9-((triethylsilyl)oxy)pentadec-7-en-3-yl) (S)-piperidine-1,2-dicarboxylate
(S,E)-5-((2S,5R,6S)-6-((tert-butyldimethylsilyl)oxy)-5-methyltetrahydro-2H-pyran-2-yl)-4-methoxy-3-methylpent-2-enal
1-(tert-butyl) 2-((2R,3S,6R,7E,9R,10R,12R,14S,15E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-16-iodo-10-methoxy-2,6,8,12,14-pentamethyl-5,11-dioxo-9-((triethylsilyl)oxy)hexadeca-7,15-dien-3-yl) (S)-piperidine-1,2-dicarboxylate
(2S,3R,4R,6S)-2-methoxy-3,7-bis((4-methoxybenzyl)oxy)-4,6-dimethylheptanal
(R,E)-2-bromo-4-(1,3-dithian-2-yl)pent-2-en-1-ol
(S)-3-((2S,5R,6S)-6-((tert-butyldimethylsilyl)oxy)-5-methyltetrahydro-2H-pyran-2-yl)-2-methoxypropanal
下游产品
2-((Z)-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-2-methylprop-1-en-1-yl)-4,6-dimethylphenol
甲基磷酸乙酯
42-(二甲基亚膦酰)雷帕霉素
2-((2R)-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-2-methylpropyl)-4,6-dimethylphenol
L-哌啶-2-甲酸
二甲基磷酸
2-((1R,2R)-1-hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-2-methylpropyl)-4,6-dimethylphenol
(1R,2R,4S)-4-{(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-二羟基-19,30-二甲氧基-15,17,21,23,29,35-六甲基-2,3,10,14,20-五氧代-11,36-二氧杂-4-氮杂三环[30.3.1.04,9]三十六碳-16,24,26,28-四烯-12-基]丙基}-2-甲氧基环己基2,2,5-三甲基-1,3-二恶烷-5-羧酸酯
西罗莫司脂化物
2,4-二甲基苯酚
1-((1R,3S,4S)-3-hydroxy-4-methoxycyclohexyl)propan-2-one