百科

(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

CAS号：573716-72-0

英文名：(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

分子式：C21H29NO7S

分子量：439.522

合成路线

tert-butyl (1R,4S,5R,6S)-5-hydroxy-6-[(4-methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylate

tert-butyl (1R,4S,5R,6S)-5-hydroxy-6-[(4-methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylate

(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

5-Oxo-6-(toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]hept-2-ene-7-carboxylic acid tert-butyl ester

5-Oxo-6-(toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]hept-2-ene-7-carboxylic acid tert-butyl ester

(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

tert-butyl (1S,4R,5S,6R)-5-[(4-methylphenyl)sulfonyl]-6-({[(1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl}oxy)-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylate

tert-butyl (1S,4R,5S,6R)-5-[(4-methylphenyl)sulfonyl]-6-({[(1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl}oxy)-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylate

(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

(+)-(1R,2S,3R,4S,5R,6S)-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane-5-endo-ol

上游原料

5-Oxo-6-(toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]hept-2-ene-7-carboxylic acid tert-butyl ester tert-butyl (1R,4S,5R,6S)-5-hydroxy-6-[(4-methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylate tert-butyl (1S,4R,5S,6R)-5-[(4-methylphenyl)sulfonyl]-6-({[(1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl}oxy)-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylate

下游产品

(+)-(1S,2S,3R,4R,5S)-5-endo-benzylamino-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane (-)-(1R,2S,3R,4R,5R,6S)-5-endo-azido-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-exo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane (+)-7-tert-butoxycarbonyl-5,6-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptan-2-endo-ol (+)-7-tert-butoxycarbonyl-2-[[(tert-butyl)dimethylsilyl]oxy]-5,6-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]hept-2-ene [((3aR,4S,6S,6aS)-6-Hydroxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbonyl)-amino]-acetic acid benzyl ester (+)-(1S,2S,3R,4R,5S)-5-endo-amino-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane (+)-(1R,2S,3R,4R,5S,6R)-5-exo-azido-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-6-endo-p-toluenesulfonyl-7-azabicyclo[2.2.1]heptane (+)-(1S,2S,3R,4R,5R)-5-exo-amino-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane (3aR,4S,6S,6aS)-4-(Benzyloxycarbonylmethyl-carbamoyl)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester L-2,3-trans-3,4-cis-4,5-trans-N-(tert-butoxycarbonyl)-5-hydroxymethyl-3,4-isopropylidenedioxyproline {[(3aR,4S,6S,6aS)-5-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbonyl]-amino}-acetic acid benzyl ester (3aR,4S,7S,7aS)-tert-butyl 2,2-dimethyl-5-oxohexahydro-4,7-epiminobenzo[d][1,3]dioxole-8-carboxylate