百科

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

CAS号：615284-85-0

英文名：((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

分子式：C38H54O8Si

分子量：666.916

合成路线

(S)-3-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-propionaldehyde

(S)-3-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-propionaldehyde

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

(S)-1-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-hept-6-en-3-ol

(S)-1-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-hept-6-en-3-ol

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

(S)-3-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-propan-1-ol

(S)-3-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-propan-1-ol

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

(2R,3S,5R)-2-((1S,2R)-3-Benzyloxy-1-iodo-2-methyl-propyl)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

(2R,3S,5R)-2-((1S,2R)-3-Benzyloxy-1-iodo-2-methyl-propyl)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3''-hydroxy-6-methyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)methyl pivalate

上游原料

(S)-1-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-hept-6-en-3-ol (2R,3S,5R)-2-((1S,2R)-3-Benzyloxy-1-iodo-2-methyl-propyl)-3-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan (S)-3-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-propionaldehyde (S)-3-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-methyl-propan-1-ol

下游产品

(E)-5-((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-6-methyl-3''-((triethylsilyl)oxy)dodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-6''-yl)pent-4-en-1-yl pivalate perfluorophenyl (2R,3aS,5R,5'R,6S,6''S,7aS)-6-methyl-6''-((pivaloyloxy)methyl)-2,3,3a,3',4',5'',6,6'',7,7a-decahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-2-carboxylate tert-butyl(((2R,3aS,3''R,5R,5'R,6S,6''S,7aS)-6-methyl-3''-((triethylsilyl)oxy)-6''-vinyldodecahydrodispiro[furo[3,2-b]pyran-5,2'-furan-5',2''-pyran]-2-yl)methoxy)diphenylsilane