百科

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

CAS号：73341-72-7

英文名：Macbecin I,(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin

分子式：C30H42N2O8

分子量：558.663

合成路线

(E)-(4S,5R,6S,8S,9R)-9-(2,5-Dimethoxy-3-nitro-phenyl)-5,6,9-trimethoxy-2,4,8-trimethyl-non-2-en-1-ol

(E)-(4S,5R,6S,8S,9R)-9-(2,5-Dimethoxy-3-nitro-phenyl)-5,6,9-trimethoxy-2,4,8-trimethyl-non-2-en-1-ol

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

1-Dimethoxymethyl-2,5-dimethoxy-3-nitro-benzene

1-Dimethoxymethyl-2,5-dimethoxy-3-nitro-benzene

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

(2R,3R,4E,6S,7R,10S,11R)-3-(tert-Butyldimethylsilyloxy)-11-(2,5-dimethoxy-3-nitrophenyl)-N,7,11-trimethoxy-N,2,4,6,10-pentamethyl-8-oxo-9-<(2-thioxo-3-thiazolidinyl)carbonyl>-4-undecenamide

(2R,3R,4E,6S,7R,10S,11R)-3-(tert-Butyldimethylsilyloxy)-11-(2,5-dimethoxy-3-nitrophenyl)-N,7,11-trimethoxy-N,2,4,6,10-pentamethyl-8-oxo-9-<(2-thioxo-3-thiazolidinyl)carbonyl>-4-undecenamide

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

methyl (E)-4-(dichlorophosphoryl)-2-methylbut-2-enoate

methyl (E)-4-(dichlorophosphoryl)-2-methylbut-2-enoate

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

[(2R,3S,6S,7R,8E,11S,12Z,14E)-2,5,6-三甲氧基-3,7,9,11,15-五甲基-16,20,22-三氧代-17-氮杂双环[16.3.1]二十二-1(21),8,12,14,18-五烯-10-基]氨基甲酸酯

上游原料

1-Dimethoxymethyl-2,5-dimethoxy-3-nitro-benzene (2R,3R,4E,6S,7R,10S,11R)-3-(tert-Butyldimethylsilyloxy)-11-(2,5-dimethoxy-3-nitrophenyl)-N,7,11-trimethoxy-N,2,4,6,10-pentamethyl-8-oxo-9-<(2-thioxo-3-thiazolidinyl)carbonyl>-4-undecenamide methyl (E)-4-(dichlorophosphoryl)-2-methylbut-2-enoate (E)-(4S,5R,6S,8S,9R)-9-(2,5-Dimethoxy-3-nitro-phenyl)-5,6,9-trimethoxy-2,4,8-trimethyl-non-2-en-1-ol

下游产品

macbecin II diacetate