化合物简介
9-Hydroxyoctadecadienoic acid (9-hydroxy-10(E),12(Z)-octadecadienoic acid or 9-HODE) has been used in the literature to designate either or both of two stereoisomer metabolites of the essential fatty acid, linoleic acid: 9(S)-hydroxy-10(E),12(Z)-octadecadienoic acid (9(S)-HODE) and 9(R)-hydroxy-10(E),12(Z)-octadecadienoic acid (9(R)-HODE); these two metabolites differ in having their hydroxy residues in the S or R configurations, respectively. The accompanying figure gives the structure for 9(S)-HETE. Two other 9-hydroxy linoleic acid derivatives occur in nature, the 10E,12E isomers of 9(S)-HODE and 9(R)-HODE viz., 9(S)-hydroxy-10E,12E-octadecadienoic acid (9(S)-EE-HODE) and 9(R)-hydroxy-10E,12E-octadecadienoic acid (13(R)-EE-HODE); these two derivatives have their double bond at carbon 12 in the E or trans configuration as opposed to the Z or cis configuration. The four 9-HODE isomers, particularly under conditions of oxidative stress, may form together in cells and tissues; they have overlapping but not identical biological activities and significances. Because many studies have not distinguished between the S and R stereoisomers and, particularly in identifying tissue levels, the two EE isomers, 9-HODE is used here when the isomer studied is unclear.
基本信息
中文名称
(9S,10E,12Z)-9-羟基十八碳-10,12-二烯酸
英文名称
9(S)-HODE
中文别名
英文别名
9-hydroxy-10-trans,12-cis-octadecadienoic acid、9-Hydroxy-10t,12c-octadecadienoic acid、9-HOD
CAS号
73543-67-6
分子式
C18H32O3
分子量
296.445
精确质量
296.235
PSA
57.53
LOGP
4.8553
编号系统
UNII
42KE04U9BM
物化性质
密度
0.97g/cm3
沸点
416.1ºC at 760 mmHg
闪点
219.6ºC
折射率
1.492
安全信息
危险性防范说明
P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235
信号词
Danger
危险性描述
H225; H319
危险标志
GHS02, GHS07