百科

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

CAS号：75466-98-7

英文名：{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

分子式：C74H87N3O21

分子量：1354.49

合成路线

dicarbobenzoxy-δ-hydroxy-L-lysine-lactone

dicarbobenzoxy-δ-hydroxy-L-lysine-lactone

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

[(3R,6S)-6-(Benzyloxycarbonylamino-methyl)-2-oxo-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

[(3R,6S)-6-(Benzyloxycarbonylamino-methyl)-2-oxo-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

[(3S,6R)-6-(Benzyloxycarbonylamino-methyl)-2-oxo-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

[(3S,6R)-6-(Benzyloxycarbonylamino-methyl)-2-oxo-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

N-Methyl-acetimidic acid (2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester

N-Methyl-acetimidic acid (2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester

[(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-((2S,3S,4S,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-hydroxy-tetrahydro-pyran-2-yloxy)-hexanoylamino]-acetic acid tert-butyl ester

[(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-((2S,3S,4S,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-hydroxy-tetrahydro-pyran-2-yloxy)-hexanoylamino]-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

dicarbobenzoxy-δ-hydroxy-L-lysylglycine t-butyl ester

dicarbobenzoxy-δ-hydroxy-L-lysylglycine t-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

4-Oxo-pentanoic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4R)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester

4-Oxo-pentanoic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4R)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

2-O-levulinoyl-3,4,6-tri-O-acetyl-α-D-galactopyranosyl bromide

2-O-levulinoyl-3,4,6-tri-O-acetyl-α-D-galactopyranosyl bromide

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

108603-80-1

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid tert-butyl ester

上游原料

2-O-levulinoyl-3,4,6-tri-O-acetyl-α-D-galactopyranosyl bromide dicarbobenzoxy-δ-hydroxy-L-lysine-lactone [(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-((2S,3S,4S,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-hydroxy-tetrahydro-pyran-2-yloxy)-hexanoylamino]-acetic acid tert-butyl ester 4-Oxo-pentanoic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-2-[(1R,4R)-4-benzyloxycarbonylamino-1-(benzyloxycarbonylamino-methyl)-4-(tert-butoxycarbonylmethyl-carbamoyl)-butoxy]-tetrahydro-pyran-3-yl ester N-Methyl-acetimidic acid (2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester [(3S,6R)-6-(Benzyloxycarbonylamino-methyl)-2-oxo-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester dicarbobenzoxy-δ-hydroxy-L-lysylglycine t-butyl ester [(3R,6S)-6-(Benzyloxycarbonylamino-methyl)-2-oxo-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

下游产品

{(2R,5R)-2,6-Bis-benzyloxycarbonylamino-5-[(2S,3S,4R,5R,6S)-4,5-diacetoxy-6-acetoxymethyl-3-((2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid {(2S,5S)-2,6-Bis-benzyloxycarbonylamino-5-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-hydroxymethyl-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid {(2S,5S)-2,6-Diamino-5-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-hydroxymethyl-3-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-hexanoylamino}-acetic acid