百科

(R)-8-((3aR,5S,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-hydroxy-oct-5-ynoic acid

CAS号：75879-49-1

英文名：(R)-8-((3aR,5S,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-hydroxy-oct-5-ynoic acid

分子式：C15H22O6

分子量：298.332

合成路线

75824-57-6

5,6-di-O-acetyl-1,2-O-isopropylidene-3-O-(methylthio)thiocarbonyl-α-D-glucofuranose

75879-49-1

(R)-8-((3aR,5S,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-hydroxy-oct-5-ynoic acid

72605-81-3

1,2-O-isopropylidene-3-O-(methylthio)thiocarbonyl-α-D-glucofuranose

75879-49-1

(R)-8-((3aR,5S,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-hydroxy-oct-5-ynoic acid

76119-18-1

1,2-O-isopropylidene-5,6-O-methoxymethylidene-3-deoxy-α-D-xylohexofuranose

75879-49-1

(R)-8-((3aR,5S,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-hydroxy-oct-5-ynoic acid

74707-99-6

5,6-Di-O-acetyl-3-deoxy-1,2-O-isopropylidene-α-D-ribo-hexofuranose

75879-49-1

(R)-8-((3aR,5S,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-hydroxy-oct-5-ynoic acid

上游原料

5,6-di-O-acetyl-1,2-O-isopropylidene-3-O-(methylthio)thiocarbonyl-α-D-glucofuranose 1,2-O-isopropylidene-3-O-(methylthio)thiocarbonyl-α-D-glucofuranose 1,2-O-isopropylidene-5,6-O-methoxymethylidene-3-deoxy-α-D-xylohexofuranose 5,6-Di-O-acetyl-3-deoxy-1,2-O-isopropylidene-α-D-ribo-hexofuranose

下游产品

methyl 8R,9R,11R-trihydroxyeicosa-5Z,12E,14E-trienoate (Z)-(R)-8-Acetoxy-8-((3aR,5S,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-oct-5-enoic acid methyl ester methyl 8S,9R,11R-triacetoxy-5Z,12E,14E-eicosatrienoate (R)-1-((3aR,5S,6aR)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-8-methoxy-8-oxooct-3-yn-1-yl benzoate (R)-8-Acetoxy-8-((3aR,5S,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-oct-5-ynoic acid methyl ester (Z)-(R)-8-((3aR,5R,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-hydroxy-oct-5-enoic acid methyl ester (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-((3aR,5R,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-oct-5-enoic acid methyl ester methyl 8R-tert-butyldiphenylsilyloxy-9R,11R-dihydroxy-9,11-O-isopropylidene-12,12-di(ethylthio)dodeca-5Z-enoate (R,Z)-1-((2S,4S,5R)-4-(benzoyloxy)-5-((Z)-oct-2-en-1-yl)tetrahydrofuran-2-yl)-8-methoxy-8-oxooct-3-en-1-yl benzoate (R,Z)-1-((2S,4R,5R)-4-hydroxy-5-((Z)-oct-2-en-1-yl)tetrahydrofuran-2-yl)-8-methoxy-8-oxooct-3-en-1-yl benzoate (9S,11R)-8-Iodo-12-oxo-9,11-bis-triethylsilanyloxy-dodec-5-ynoic acid methyl ester methyl 8R-tert-butyldiphenylsilyloxy-9R,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate (9S,11R)-12,12-Bis-ethylsulfanyl-8-iodo-9,11-bis-triethylsilanyloxy-dodec-5-ynoic acid methyl ester (9S,11R)-12,12-Bis-ethylsulfanyl-9,11-dihydroxy-8-iodo-dodec-5-ynoic acid methyl ester (R)-1-((2S,4R,5R)-5-allyl-4-hydroxytetrahydrofuran-2-yl)-8-methoxy-8-oxooct-3-yn-1-yl benzoate (12E,14Z)-(9S,11R)-8-Iodo-9,11-bis-triethylsilanyloxy-icosa-12,14-dien-5-ynoic acid methyl ester (E)-(9S,11R)-8-Iodo-14-oxo-9,11-bis-triethylsilanyloxy-tetradec-12-en-5-ynoic acid methyl ester (Z)-(R)-8-((3aR,5S,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-hydroxy-oct-5-enoic acid methyl ester methyl 8R-mesyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-eicosa-5Z,12E,14Z-trienoate methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate methyl 8R,9S,11R-dihydroxy-9,11-O-isopropylidene-eicosa-5Z,12E,14Z-trienoate methyl 8R-tert-butyldimethylsilyloxy-9R,11R-dihydroxy-9,11-O-isopropylidene-eicosa-5Z,12E,14-trienoate (R)-8-((3aR,5S,6aR)-2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-8-trifluoromethanesulfonyloxy-oct-5-ynoic acid methyl ester methyl 8R-acetoxy-9R,11R-dihydroxy-9,11-O-isopropylidene-eicosa-5Z,12E,14-trienoate methyl 8R,9S,11R-trihydroxy-5Z,12E,14Z-eicosatrienoate (Z)-(8R,9R,11R)-8-(tert-Butyl-diphenyl-silanyloxy)-12,12-bis-ethylsulfanyl-9,11-dihydroxy-dodec-5-enoic acid methyl ester