百科

(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

CAS号：774598-84-4

英文名：(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

分子式：C28H32N2O7

分子量：508.563

合成路线

1-(2-O-acetyl-3-O-benzyl-3-C-(3-benzyloxy)propyl-5-O-mesyl-4-C-mesyloxymethyl-β-D-erythro-pentofuranosyl)thymine

1-(2-O-acetyl-3-O-benzyl-3-C-(3-benzyloxy)propyl-5-O-mesyl-4-C-mesyloxymethyl-β-D-erythro-pentofuranosyl)thymine

(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

3-O-benzyl-3-C-(3-benzyloxy)propyl-4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose

3-O-benzyl-3-C-(3-benzyloxy)propyl-4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose

(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

1,2-di-O-acetyl-3-O-benzyl-3-C-(3-benzyloxy)propyl-5-O-mesyl-4-C-mesyloxymethyl-D-erythro-pentofuranose

1,2-di-O-acetyl-3-O-benzyl-3-C-(3-benzyloxy)propyl-5-O-mesyl-4-C-mesyloxymethyl-D-erythro-pentofuranose

(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

(1S,3R,4R,7S)-7-benzyloxy-7-(3-benzyloxy)propyl-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

上游原料

1,2-di-O-acetyl-3-O-benzyl-3-C-(3-benzyloxy)propyl-5-O-mesyl-4-C-mesyloxymethyl-D-erythro-pentofuranose 1-(2-O-acetyl-3-O-benzyl-3-C-(3-benzyloxy)propyl-5-O-mesyl-4-C-mesyloxymethyl-β-D-erythro-pentofuranosyl)thymine 3-O-benzyl-3-C-(3-benzyloxy)propyl-4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose

下游产品

(1R,3R,4R,7S)-1-(4,4'-dimethoxytrityl)oxymethyl-7-hydroxy-7-(3-hydroxy)propyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (1R,3R,4R,7S)-7-(3-acetoxypropyl)-1-(4,4'-dimethoxytrityl)oxymethyl-7-hydroxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane