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((7R,8R)-8-Amino-1,4-dioxa-spiro[4.5]dec-7-yl)-methanol

((7R,8R)-8-Amino-1,4-dioxa-spiro[4.5]dec-7-yl)-methanol

CAS号：813445-22-6

英文名：((7R,8R)-8-Amino-1,4-dioxa-spiro[4.5]dec-7-yl)-methanol

分子式：C9H17NO3

分子量：187.236

合成路线

ethyl (R)-8-((1-phenylethyl)amino)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

ethyl (R)-8-((1-phenylethyl)amino)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

((7R,8R)-8-Amino-1,4-dioxa-spiro[4.5]dec-7-yl)-methanol

((7R,8R)-8-Amino-1,4-dioxa-spiro[4.5]dec-7-yl)-methanol

上游原料

ethyl (R)-8-((1-phenylethyl)amino)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

下游产品

N-((1S,3S,4R)-4-({[(5-acetyl-4-methyl-1,3-thiazol-2-yl)amino]carbonyl}amino)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N-methylacetamide benzyl ((1R,2R,4S)-4-amino-2-((phenylsulfonyl)methyl)cyclohexyl)carbamate benzyl (1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexylcarbamate N-{(1R,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[1-methyl-indazol-5-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide benzyl ((7S,8R)-7-(((3-(4-fluorophenyl)propyl)(methyl)amino)methyl)-1,4-dioxaspiro[4.5]decan-8-yl)carbamate benzyl {(7S,8R)-7-[((3-((4-fluorophenyl)propyl)(propyl)amino)methyl)]-1,4-dioxa-spiro[4.5]dec-8-yl}-carbamate benzyl ((1R,2R)-4-amino-2-((phenylsulfonyl)methyl)cyclohexyl)carbamate N-((1R,3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexyl)pivalamide N-{(1S,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[1-methyl-indazol-5-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide benzyl ((1R,2S)-2-(((3-(4-fluorophenyl)propyl)(methyl)amino)methyl)-4-(N-methylacetamido)cyclohexyl)carbamate 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(1,3,4-thiadiazol-2-yl)urea 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-methyl-1,3,4-thiadiazol-2-yl)urea N-((3S,4R)-4-amino-3-(((3-(4-fluorophenyl)propyl)(methyl)amino)methyl)cyclohexyl)-N-methylacetamide 1-((1R,2S,4R)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-pivalamidocyclohexyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)urea benzyl (1R,2S)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-4-oxocyclohexylcarbamate N-((1R,3S,4R)-4-({[(5-acetyl-4-methyl-1,3-thiazol-2-yl)amino]carbonyl}amino)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N-methylacetamide benzyl (1R,2S,4R)-4-amino-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-cyclohexylcarbamate ((7R,8R)-7-Formyl-1,4-dioxa-spiro[4.5]dec-8-yl)-carbamic acid benzyl ester N-{(1R,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[4-methyl-1,3-thiazol-2-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide N-{(1S,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[4-methyl-1,3-thiazol-2-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide N-{(1R,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[3-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide N-{(1S,3S,4R)-3-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}-4-[({[3-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide benzyl ((7R,8R)-7-((phenylsulfonyl)methyl)-1,4-dioxaspiro[4.5]decan-8-yl)carbamate benzyl ((7R,8R)-7-((phenylthio)methyl)-1,4-dioxaspiro[4.5]decan-8-yl)carbamate benzyl ((1R,2R)-4-oxo-2-((phenylsulfonyl)methyl)cyclohexyl)carbamate benzyl ((1R,2R,4R)-4-amino-2-((phenylsulfonyl)methyl)cyclohexyl)carbamate