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(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

CAS号：813445-33-9

英文名：(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

分子式：C19H27NO4

分子量：333.422

合成路线

ethyl 2,4-dioxocyclohexane-1-carboxylate

ethyl 2,4-dioxocyclohexane-1-carboxylate

(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

ethyl 7-oxo-1,4-dioxaspiro[4.5]decane-8-carboxylate

ethyl 7-oxo-1,4-dioxaspiro[4.5]decane-8-carboxylate

(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid ethyl ester

7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid ethyl ester

(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

上游原料

ethyl 2,4-dioxocyclohexane-1-carboxylate ethyl 7-oxo-1,4-dioxaspiro[4.5]decane-8-carboxylate 7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid ethyl ester

下游产品

{(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester benzyl ((1R,2S)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-5-(methylamino)cyclohexyl)carbamate N-[3-(1-methyl-tetrazol-5-yl)phenyl]-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea N-((1S,3R,4S)-3-({[(5-acetyl-4-methyl-1,3-thiazol-2-yl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(propyl)amino]methyl}cyclohexyl)-N-methylacetamide benzyl ((1R,2S)-2-(((3-(4-fluorophenyl)propyl)(methyl)amino)methyl)-5-oxocyclohexyl)carbamate N-[3-(1-methyl-tetrazol-5-yl)phenyl]-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea N-(3-acetylphenyl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea benzyl ((1R,2S)-2-(((3-(4-fluorophenyl)propyl)(methyl)amino)methyl)-5-(methylamino)cyclohexyl)carbamate N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide N-((3R,4S)-3-amino-4-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)cyclohexyl)-N-methylacetamide N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea benzyl ((1R,2S)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-5-(N-methylacetamido)cyclohexyl)carbamate N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea benzyl ((7R,8S)-8-(((3-(4-fluorophenyl)propyl)(methyl)amino)methyl)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate benzyl ((7R,8S)-8-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate N-(5-acetyl-4-methyl-thiazol-2-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea benzyl ((1R,2S)-2-(((3-(4-fluorophenyl)propyl)(propyl)amino)methyl)-5-oxocyclohexyl)carbamate N-{(1R,3R,4S)-4-{[3-(4-fluorophenyl)propyl(propyl)amino]methyl}-3-[({[4-methyl-1,3-thiazol-2-yl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide N-(5-acetyl-4-methyl-thiazol-2-yl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea N-(3-acetylphenyl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-propyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea benzyl ((1R,2S)-2-(((3-(4-fluorophenyl)propyl)(methyl)amino)methyl)-5-(N-methylacetamido)cyclohexyl)carbamate N-((1S,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N-methylacetamide N-{(1R,3R,4S)-4-{[[3-(4-fluorophenyl)propyl](propyl)amino]methyl}-3-[({[3-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide N-((3R,4S)-3-amino-4-(((3-(4-fluorophenyl)propyl)(methyl)amino)methyl)cyclohexyl)-N-methylacetamide