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百科
瑞莫杜林
CAS号：81846-19-7
英文名：treprostinil
分子式：C23H33NaO5
分子量：412.495
上游原料
2-((1R,2R,3aS,9aS)-2-hydroxy-1-(S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-5-yloxylacetic acid ethyl ester
2-((1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3S,1E)-3-hydroxyoct-1-enyl)-1H-cyclopenta[b]naphthalen-5-yloxy)acetic acid
(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3S,1E)-3-hydroxyoct-1-enyl)-1H-cyclopenta[b]naphthalen-5-yl benzoate
间甲氧基苯甲醇
曲前列尼尔中间体
(1R,2R,3R)-3-(3-(benzyloxy)benzyl)-2-((3S,1E)-3-hydroxyoct-1-enyl)-4-methylenecyclopentanol
(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-(tert-butyldimethylsilyloxy)-1-((3S,1E)-3-(tert-butyl dimethylsilyloxy)oct-1-enyl)-1H-cyclopenta[b]naphthalen-5-yl benzoate
(S)-5-[(四氢吡喃基)氧基]-1-癸炔
((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate
(3aS,9aS)-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3a,4,9-tetrahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-2H-benz[f]inden-2-one
2-allyl-3-(4-methoxybenzyloxy)benzaldehyde
(1R,2R,3R)-(1-(3-benzyloxy)benzyl)-3-tert-butyl-dimethylsilyloxy-2-[(3S)-tert-butyldimethylsilyloxy-1-octenyl]-5-methylenecyclopentane
3-烯丙氧基-苯甲醛
(6S)-1-[3-methoxy-2-(2-propenyl)phenyl]-6-[(tetrahydro-2H-pyran-2-yl)oxy]-2-undecyn-1-one
(1,1-dimethylethyl)[[(1S,6S)-1-[3-methoxy-2-(2-propenyl)phenyl]-6-[(tetrahydro-2H-pyran-2-yl)oxy]-2-undecynyl]oxy]dimethylsilane
((1S,2S,3R,4R)-2-(3-(benzyloxy)benzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate
2-((1R,2R,3aS,9aS)-2-hydroxy-1-(S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-5-yloxylacetic acid methyl ester
(3-methoxy-2-prop-2-enylphenyl)methanol
methyl 2-(((3aS,9aS)-2-oxo-1-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate
methyl 2-(2-allyl-3-((1S,6S)-1-((tert-butyldimethylsilyl)oxy)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-yl)phenoxy)acetate
(3R)-1-[3-(benzyloxy)benzyl]-5-oxo-3-(triethylsilyloxy)cyclopent-1-ene
2-烯丙基-3-甲氧基苯甲醛
1-(trimethylsilyl)-O-tetrahydropyran-2-yl-1-decyn-5-(S)-ol
2-allyl-3-methoxy-O-tert-butyldimethylsilylbenzyl alcohol
(S)-1-chloro-2-heptanol
(1R,2R,3R)-(1-(3-benzyloxy)benzyl)-5-oxo-3-triethylsilyloxy-2-[(3S)-triethylsilyloxy-1-octenyl]-cyclopentane
3-methoxy-O-tert-butyldimethylsilylbenzyl alcohol
2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid,2-(2-hydroxyethylamino)ethanol
(1R,2R,3AS,9AS)-2,3,3A,4,9,9A-六氢-1-[(3S)-3-甲氧基辛基]-1H-苯并[F]茚-2,5-二醇
2-((1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3S)-3-hydroxyoctyl)-1H-cyclopenta[b]naphthalen-5-yloxy)acetonitrile
(4R,9aS)-3-((S)-3-benzyloxyoctyl)-4-(tert-butyldimethylsilanyloxy)-8-(4-methoxybenzyloxy)-1,4,9,9a-tetrahydrocyclopenta[b]napthalen-2-one
2-allyl-3-[(carbomethoxy)methoxy]benzaldehyde
(3aS,9aS)-1-((S)-3-benzyloxyoctyl)-5-hydroxy-1,3,3a,4,9,9a-hexahydrobenz[f]inden-2-one
((1S,2S,3R,4R)-2-(3-(benzyloxy)benzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methanol
(1R,2R,3aS,9aS)-1-((S)-3-benzyloxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol
(αS)-3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol
((1S,2S,3R,4R)-2-(3-(benzyloxy)benzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl 4-methylbenzenesulfonate
(S)-1-[2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-one
{(1R,6S)-1-[-2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-ynyloxy}-tert-butyl-dimethyl-silane
(S)-1-[2-allyl-3-(4-methoxybenzyloxy)phenyl]-6-benzyloxyundec-2-yn-1-ol
2-烯丙基-3-羟基苯甲醛
((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl 4-methylbenzenesulfonate
methyl 2-(2-allyl-3-((1S,6S)-1-hydroxy-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-yl)phenoxy)acetate
(1S,2E)-1-pentyl-3-(1,1,1-tributylstannyl)-2-propenyl (1,1,1-triethylsilyl) ether
(S)-1-chloro-O-tetrahydropyran-2-yl-heptan-2-ol
(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-(tert-butyldimethylsilyloxy)-1-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)-1H-cyclopenta[b]naphthalen-5-ol
(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-1H-benz[f]inden-2-ol
