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(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

CAS号：850359-87-4

英文名：(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

分子式：C19H25NO7

分子量：379.404

合成路线

(3aR,5S,5'S,6S,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

N-[(3aR,5S,6S,6aR)-6-Acetyl-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-2,2,2-trichloro-acetamide

N-[(3aR,5S,6S,6aR)-6-Acetyl-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-2,2,2-trichloro-acetamide

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-vinyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide

2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-vinyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-((S)-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide

2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-((S)-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-((R)-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide

2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-((R)-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide

2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

2,2,2-Trichloro-acetimidic acid 2-[(3aR,5S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-(6Z)-ylidene]-ethyl ester

2,2,2-Trichloro-acetimidic acid 2-[(3aR,5S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-(6Z)-ylidene]-ethyl ester

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(Z)-3-deoxy-3-C-[(hydroxymethyl)methylene]-1,2:5,6-di-O-isopropylidene-α-D-ribo-hexofuranose

(Z)-3-deoxy-3-C-[(hydroxymethyl)methylene]-1,2:5,6-di-O-isopropylidene-α-D-ribo-hexofuranose

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

(3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-1,2-dihydroxyethyl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

上游原料

2,2,2-Trichloro-acetimidic acid 2-[(3aR,5S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-dihydro-furo[2,3-d][1,3]dioxol-(6Z)-ylidene]-ethyl ester (3aR,5S,5'S,6S,6aR)-3'-benzyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one 2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-((S)-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide N-[(3aR,5S,6S,6aR)-6-Acetyl-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-2,2,2-trichloro-acetamide 2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide (Z)-3-deoxy-3-C-[(hydroxymethyl)methylene]-1,2:5,6-di-O-isopropylidene-α-D-ribo-hexofuranose 2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-vinyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide 2,2,2-Trichloro-N-[(3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-((R)-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl]-acetamide (3aR,5S,5'S,6S,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2,5'-trimethyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one

下游产品

(1'R,3'R,4S,5S)-3-benzyl-1',3'-dihydroxy-5-methyl-6'-(trimethylsilyl)-3a',4'-dihydro-1'H-spiro[oxazolidine-4,2'-pentalene]-2,5'(3'H)-dione (3aR,5R,5'S,6S,6aR)-3'-benzyl-2,2,5'-trimethyl-5-vinyldihydro-5H-spiro[furo[2,3-d][1,3]dioxole-6,4'-oxazolidin]-2'-one