百科

(1S,4R,5S)-1-(2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidine-2,4-dione

(1S,4R,5S)-1-(2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidine-2,4-dione

CAS号：865838-20-6

英文名：(1S,4R,5S)-1-(2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidine-2,4-dione

分子式：C10H11FN2O5

分子量：258.203

合成路线

(1R,4S,5S)-1-(benzyloxymethyl)-2-en-4,5-(O-isopropylidenedioxy)-cyclopentan-1-ol

(1R,4S,5S)-1-(benzyloxymethyl)-2-en-4,5-(O-isopropylidenedioxy)-cyclopentan-1-ol

(1S,4R,5S)-1-(2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidine-2,4-dione

(1S,4R,5S)-1-(2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidine-2,4-dione

5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

(1S,4R,5S)-1-(2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidine-2,4-dione

(1S,4R,5S)-1-(2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidine-2,4-dione

上游原料

(1R,4S,5S)-1-(benzyloxymethyl)-2-en-4,5-(O-isopropylidenedioxy)-cyclopentan-1-ol 5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

下游产品

O-((8S,9S,9aR)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-7-fluoro-2,2,4,4-tetraisopropyl-6,8,9,9a-tetrahydrocyclopenta[f][1,3,5,2,4]trioxadisilocin-9-yl) O-phenyl carbonothioate 1-[(1S,4S)-2-fluoro-4,6-(tetraisopropyldisiloxane-1,3-diyl)cylopent-2(3)-en-1-yl]uracil