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(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
CAS号:866110-94-3
英文名:(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
分子式:C28H35N3O7
分子量:525.593
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合成路线
866110-76-1
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-77-2
{(S)-2-((1R,3S)-8-Allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-carbamic acid tert-butyl ester
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-87-4
(S)-1-[(1R,3S)-8-Allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-79-4
(6S,9R,14aS,15R)-10-(allyloxy)-9-((allyloxy)methyl)-1-hydroxy-2,4,11,13-tetramethoxy-3,12,16-trimethyl-5,6,9,14,14a,15-hexahydro-7H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-7-one
151-50-8
氰化钾
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-67-0
(1R,3S)-8-Allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinoline
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-66-9
(1R,3S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-8-hydroxy-1-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-96-5
(1R,3S)-8-Allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-90-9
(6S,9R,14aS,15R)-10-(allyloxy)-9-((allyloxy)methyl)-1-hydroxy-2,4,11,13-tetramethoxy-3,12-dimethyl-5,6,9,14,14a,15-hexahydro-7H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-7-one
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-89-6
(1R,3S,6R,11aS)-7-Allyloxy-6-allyloxymethyl-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-1-hydroxy-8,10-dimethoxy-9-methyl-4-oxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinoline-2-carboxylic acid tert-butyl ester
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
866110-88-5
{2-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-carbamic acid tert-butyl ester
866110-94-3
(6S,7R,9R,14aS,15R)-1,10-dihydroxy-9-(hydroxymethyl)-2,4,11,13-tetramethoxy-3,12,16-trimethyl-6,7,9,14,14a,15-hexahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinoline-7-carbonitrile
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上游原料
{(S)-2-((1R,3S)-8-Allyloxy-1-allyloxymethyl-3-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-carbamic acid tert-butyl ester
{2-[8-allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-oxo-ethyl}-carbamic acid tert-butyl ester
(1R,3S)-8-Allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinoline
(1R,3S,6R,11aS)-7-Allyloxy-6-allyloxymethyl-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-1-hydroxy-8,10-dimethoxy-9-methyl-4-oxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinoline-2-carboxylic acid tert-butyl ester
(6S,9R,14aS,15R)-10-(allyloxy)-9-((allyloxy)methyl)-1-hydroxy-2,4,11,13-tetramethoxy-3,12-dimethyl-5,6,9,14,14a,15-hexahydro-7H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-7-one
(6S,9R,14aS,15R)-10-(allyloxy)-9-((allyloxy)methyl)-1-hydroxy-2,4,11,13-tetramethoxy-3,12,16-trimethyl-5,6,9,14,14a,15-hexahydro-7H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-7-one
(1R,3S)-8-Allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
(S)-1-[(1R,3S)-8-Allyloxy-1-allyloxymethyl-3-(tert-butyl-dimethyl-silanyloxymethyl)-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-propan-1-one
(1R,3S,6R,11aS)-7-Allyloxy-6-allyloxymethyl-1-hydroxy-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-8,10-dimethoxy-9-methyl-4-oxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinoline-2-carboxylic acid tert-butyl ester
(S)-3-[5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid
氰化钾
(1R,3S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-8-hydroxy-1-hydroxymethyl-5,7-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
下游产品
9-[(acetoxy)methyl]-6,7,9,14,14a,15-hexahydro-7-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-(6S,7S,9R,14aS,15R)-(-)-6,15-imino-4H-isoquino[3,2-b][3]benzazocine-1,4,10,13(5H)-tetrone
9-(acetoxymethyl)-7-cyano-6,7,9,14,14a,15-hexahydro-2,11-dimethoxy-3,12,16-trimethyl-(6S,7R,9R,14aS,15R)-(-)-6,15-imino-4H-isoquino[3,2-b][3]benzazocine-1,4,10,13(5H)-tetrone